Cell Therapy of Pathological Gastrointestinal Lesions in Modeled NSAID-Induced Enterocolitis
https://doi.org/10.33647/2074-5982-17-3-48-55
Abstract
Wistar rats with NSAID-induced (dexketoprofen) chronic enterocolitis of the gastrointestinal tract were treated with a cultured allogeneic cell suspension consisting of mononuclear cells (40 millions) and multipotent mesenchymal stromal cells (10 millions). The suspension was transplanted intraperitoneally, 2 times with an interval of 30 days. Cultured allogeneic fractions of bone marrow cells accelerate the regeneration of long-term non-healing gastrointestinal lesions by reducing the duration and severity of the inflammatory phase and activating the regenerative phase of the ulcerative process. It was found that the simultaneous administration of the studied cultured stem cells can be used for the treatment of chronic, long-term non-healing, poorly-scarring ulcerative necrotic gastrointestinal pathologies.
About the Authors
R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Roman A. Klesov*
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga I. Stepanova, Cand. Sci. (Biol.)
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko, Dr. Sci. (Med.), Prof.
143442, Russian Federation, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
O. V. Baranova
National Medical Research Center “Treatment and Rehabilitation Center” of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Oksana V. Baranova
125367, Russian Federation, Moscow, Ivan’kovskoe Highway, 3
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Review
For citations:
Klesov R.A., Stepanova O.I., Karkischenko V.N., Baranova O.V. Cell Therapy of Pathological Gastrointestinal Lesions in Modeled NSAID-Induced Enterocolitis. Journal Biomed. 2021;17(3):48-55. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-48-55
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