S-Protein of the Probiotic Strain Lactobacillus crispatus 2029 Prevents the Growth of Permeability of the Caco-2 Monolayer of Human Enterocytes Induced by Intestinal Infections
https://doi.org/10.33647/2074-5982-17-3-79-83
Abstract
The use of a biomodel of the confluent monolayer Caco-2 of enterocytes allowed us to reveal the ability of the S-protein isolated from strain LC2029 to prevent permeability disorders resulting from intestinal infections induced by pathogens (E. coli O157: H7, C. jejuni ATCC 33291, S. enteritidis ATCC 25928). This is important for maintaining the efficiency of the intestinal barrier.
About the Authors
I. V. Kosarev
Institute of Immunological Engineering
Russian Federation
Russian Federation
Igor V. Kosarev, Cand. Sci. (Biol.)
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
R. N. Vasilenko
Institute of Immunological Engineering
Russian Federation
Russian Federation
Raisa N. Vasilenko, Cand. Sci. (Biol.)
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
V. M. Abramov
Institute of Immunological Engineering
Russian Federation
Russian Federation
Vyacheslav M. Abramov, Dr. Sci. (Biol.), Prof.
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
V. K. Sakulin
Institute of Immunological Engineering
Russian Federation
Russian Federation
Vadim K. Sakulin
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
V. S. Khlebnikov
Institute of Immunological Engineering
Russian Federation
Russian Federation
Valentin S. Khlebnikov, Dr. Sci. (Biol.), Prof.
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
S. Yu. Pchelintsev
Institute of Immunological Engineering
Russian Federation
Russian Federation
Sergey Yu. Pchelintsev, Dr. Sci. (Med.), Prof.
142380, Russian Federation, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1
A. V. Machulin
Federal Research Center “Pushchino Scientifi c Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Andrey V. Machulin*, Cand. Sci. (Biol.)
142290, Russian Federation, Moscow region, Pushchino, Science Avenue, 3
T. N. Abashina
Federal Research Center “Pushchino Scientifi c Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Tatiana N. Abashina, Cand. Sci. (Biol.)
142290, Russian Federation, Moscow region, Pushchino, Science Avenue, 3
V. A. Samoilenko
Federal Research Center “Pushchino Scientifi c Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Vladimir A. Samoilenko, Cand. Sci. (Biol.)
142290, Russian Federation, Moscow region, Pushchino, Science Avenue, 3
V. N. Uversky
University of South Florida
United States
United States
Vladimir N. Uversky, Dr. Sci. (Phys.-Math.), Prof.
33620, USA, Florida, Tampa, E. Fowler Avenue, 4202
A. V. Karlyshev
Kingston University London
United Kingdom
United Kingdom
Andrey V. Karlyshev, Cand. Sci. (Biol.), Prof.
KT1 1LQ, Great Britain, London, Surrey, Kingston upon Thames, High Str., River House, 53–57
References
1. Abramov V.M., Kosarev I.V., Priputnevich T.V., et al. S-layer protein of Lactobacillus crispatus 2029, its structural and immunomodulatory characteristics and roles in protective potential of the whole bacteria against foodborne pathogens. Int. J. Biol. Macromol. 2020;150:400–412.
2. Chen C., Jamaluddin M., Yan S., et al. Human stanniocalcin- 1 blocks TNF-induced monolayer permeability in human coronary artery endothelial cells. Atherosclerosis, Thrombosis, and Vascular Biol. 2008. DOI: 10.1161/ATVBAHA. 108.163667.
Review
For citations:
Kosarev I.V., Vasilenko R.N., Abramov V.M., Sakulin V.K., Khlebnikov V.S., Pchelintsev S.Yu., Machulin A.V., Abashina T.N., Samoilenko V.A., Uversky V.N., Karlyshev A.V. S-Protein of the Probiotic Strain Lactobacillus crispatus 2029 Prevents the Growth of Permeability of the Caco-2 Monolayer of Human Enterocytes Induced by Intestinal Infections. Journal Biomed. 2021;17(3):79-83. (In Russ.) https://doi.org/10.33647/2074-5982-17-3-79-83
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