Ultrasonic assessment of the distribution of tricalcium phosphate filler over the volume of swollen porous matrices based on chitosan for biomedical applications
https://doi.org/10.33647/2713-0428-17-3E-42-47
Abstract
Regenerative medicine is a rapidly developing interdisciplinary field of science. Of primary interest are new materials and mechanisms of their interaction with living organisms. Investigation methods should provide 3D visualization and analysis of quantitative characteristics, while having no effect on the objects under study. For these purposes, methods based on ultrasound and those displaying variations in the elastic properties of samples are promising.
About the Authors
O. R. Kulikova
Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
119334, Moscow, Kosygina Str., 4
E. A. Khramtsova
Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119334, Moscow, Kosygina Str., 4
K. G. Antipova
National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
123098, Moscow, Akademika Kurchatova Square, 1
T. D. Patsaev
National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
123098, Moscow, Akademika Kurchatova Square, 1
E. S. Morokov
Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. Sci. (Phys.-Math.),
119334, Moscow, Kosygina Str., 4
K. I. Lukanina
National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
Cand. Sci. (Tech.),
123098, Moscow, Akademika Kurchatova Square, 1
V. M. Levin
Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Cand. Sci. (Phys.-Math.),
119334, Moscow, Kosygina Str., 4
T. E. Grigoriev
National Research Center “Kurchatov Institute”
Russian Federation
Russian Federation
Cand. Sci. (Phys.-Math.),
123098, Moscow, Akademika Kurchatova Square, 1
References
1. Grigoriev T.E., Zagoskin Y.D., Belousov S.I., et al. Influence of molecular characteristics of chitosan on properties of in situ formed scaffolds. BioNanoSci. 2017;7:492–495. DOI: 10.1007/S12668-017-0411-5.
2. Gudur M., Rao R.R., Hsiao Y.S., Peterson A.W., Deng C.X., Stegemann J.P. Noninvasive, quantitative, spatiotemporal characterization of mineralization in three-dimensional collagen hydrogels using high-resolution spectral ultrasound imaging. Tissue engineering. 2012;18(12):935–946. DOI: 10.1089/ten. TEC.2012.0180.
3. Gumenyuk A., Ushmarov D., Gumenyuk S., Gayvoronskaya T., Sotnichenko A., Melkonyan K., Manuylov A., Antipova K., Lukanina K., Grigoriev T., Domenyuk D. Potential use of chitozan-based multilayer wound covering in dental practice. Archiv Euromedica. 2019;9(3):76–80.
4. Khramtsova E., Morokov E., Lukanina K., Grigoriev T., Petronyuk Y., Shepelev A., Gubareva E., Kuevda E., Levin V., Chvalun S. Impulse acoustic microscopy: A new approach for investigation of polymer and natural scaffolds: Impulse Acoustic Microscopy. Polymer Engineering and Science. 2017;57(7):709–715. DOI: 10.1002/pen.24617.
5. Mansour J.M., Gu D.W., Chung C.Y., Heebner J., Althans J., Abdalian S., Schluchter M.D., Liu Y., Welter J.F. Towards the feasibility of using ultrasound to determine mechanical properties of tissues in a bioreactor. Annals of biomedical engineering. 2014;42(10):2190–2202. DOI: 10.1007/s10439-014-1079-4.
6. Morokov E., Khramtsova E., Kuevda E., Gubareva E., Grigoriev T., Lukanina K., Levin V. Noninvasive ultrasound imaging for assessment of intact microstructure of extracellular matrix in tissue engineering. Artificial Organs. 2019;43(11):1104– 1110. DOI: 10.1111/aor.13516.
7. Morokov E.S., Demina V.A., Sedush N.G., Kalinin K.T., Khramtsova E.A., Dmitryakov P.V., Bakirov A.V., Grigoriev T.E., Levin V.M., Chvalun S.N. Noninvasive high-frequency acoustic microscopy for 3D visualization of microstructure and estimation of elastic properties during hydrolytic degradation of lactide and ε-caprolactone polymers. Acta Biomaterialia. 2020;109:61–72. DOI: 10.1016/j.actbio.2020.04.011.
8. Ruland A., Chen X., Khansari A., Fay C.D., Gambhir S., Yue Z., Wallace G.G. A contactless approach for monitoring the mechanical properties of swollen hydrogels. Soft matter. 2018;14(35):7228– 7236. DOI: 10.1039/c8sm01227j.
9. Vasilyev A.V., Kuznetsova V.S., Bukharova T.B., Grigoriev T.E., Zagoskin Y., Korolenkova M.V., Zorina O.A., Chvalun S.N., Goldshtein D.V., Kulakov A.A. Development prospects of curable osteoplastic materials in dentistry and maxillofacial surgery. Heliyon. 2020;6(8):e04686. DOI: 10.1016/j. heliyon.2020.e04686.
10. Vasilyev A.V., Kuznetsova V.S., Bukharova T.B., Grigoriev T.E., Zagoskin Y.D., Nedorubova I.A., Babichenko I.I., Chvalun S.N., Goldstein D.V., Kulakov A.A. Influence of the degree of deacetylation of chitosan and BMP-2 concentration on biocompatibility and osteogenic properties of BMP2/PLA granule-loaded chitosan/β-glycerophosphate hydrogels. Molecules (Basel, Switzerland). 2021;26(2):261. DOI: 10.3390/molecules26020261.
Review
For citations:
Kulikova O.R., Khramtsova E.A., Antipova K.G., Patsaev T.D., Morokov E.S., Lukanina K.I., Levin V.M., Grigoriev T.E. Ultrasonic assessment of the distribution of tricalcium phosphate filler over the volume of swollen porous matrices based on chitosan for biomedical applications. Journal Biomed. 2021;17(3E):42-47. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-42-47
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