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Structural and functional properties of thermolable bacteriocin produced by the Limosilactobacillus fermentum IIE MD-150 strain

https://doi.org/10.33647/2713-0428-17-3E-114-117

Abstract

Bacteriocins are bacterial proteins or peptides exhibiting antimicrobial activity and synthesized on ribosomes. For a high molecular weight bacteriocin produced by the Limosilactobacillus fermentum IIE MD-150 strain and having the GRAS status (Generally Recognized as Safe), an amino acid sequence homology with enterolysin A produced by the Enterococus faecalis LMG 2333 strain was found. Lactobacillus fermentum IIE MD-150 can be used in the prevention and complex treatment of infectious diseases caused by antibiotic-resistant strains of Staphylococcus aureus. 

About the Authors

A. V. Machulin
Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”
Russian Federation

Cand. Sci. (Biol.),

142290, Moscow Region, Pushchino, Science Avenue, 3



I. V. Kosarev
Institute of Immunological Engineering
Russian Federation

Cand. Sci. (Biol.),

142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1



T. N. Abashina
Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences” 142290, Moscow Region, Pushchino, Science Avenue, 3
Russian Federation


V. M. Abramov
Institute of Immunological Engineering
Russian Federation

Cand. Sci. (Biol.), 

142380, Moscow Region, Chekhov District, Lyubuchany, Nauchnaya Str., 1



V. N. Uversky
University of South Florida
United States

Dr. Sci. (Biol.), Prof.,

33620, Florida, Tampa, 4202 E. Fowler Avenue



A. V. Karlyshev
Kingston University London
United Kingdom

Dr. Sci. (Phys.-Math.), Prof.,

KT1 1LQ, London, Surrey, Kingston upon Thames, 53–57 High Str., River House



Review

For citations:


Machulin A.V., Kosarev I.V., Abashina T.N., Abramov V.M., Uversky V.N., Karlyshev A.V. Structural and functional properties of thermolable bacteriocin produced by the Limosilactobacillus fermentum IIE MD-150 strain. Journal Biomed. 2021;17(3E):114-117. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-114-117

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)