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Study of early and remote effects of hypofractionated proton irradiation in a model of solid Ehrlich ascites carcinoma in mice

https://doi.org/10.33647/2713-0428-17-3E-127-132

Abstract

The effect of a pencil scanning beam of protons at doses of 60 and 80 Gy on the solid form of Ehrlich ascites carcinoma (EAC) in mice was studied. It was shown that mice with induced EAC are a convenient model for studying hypofractionation schemes under proton therapy. 

About the Authors

V. E. Balakin
Branch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation

Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Phys.-Math.), 

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2



T. A. Belyakova
Branch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2



O. M. Rozanova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation

142290, Moscow Region, Pushchino, Institutskaya Str., 3



E. N. Smirnova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation

142290, Moscow Region, Pushchino, Institutskaya Str., 3



A. E. Shemyakov
Branch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2;

142290, Moscow Region, Pushchino, Institutskaya Str., 3



N. S. Strelnikova
Branch “Physics and Technology Center” of the P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation

142281, Moscow Region, Protvino, Akademicheskiy Passage, 2



References

1. Balakin V.E., Shemyakov A.E., Zaichkina S.I., et al. Gipofrakcionirovannoe obluchenie solidnoj formy ascitnoj karcinomy Jeplixa u myshej tonkim skanirujushhim puchkom protonov [Hypofractionated irradiation of the solid form of Erlich ascites carcinoma in mice by a thin scanning proton beam]. Biophysics. 2016;61(4):682–686. (In Russian).

2. Abdel-Gawad E.I., Hassan A.I., Awwad S.A. Efficiency of calcium phosphate composite nanoparticles in targeting Ehrlich carcinoma cells transplanted in mice. J. Adv. Res. 2016;7(1):143–154. DOI: 10.1016/j.jare.2015.04.001.

3. Belyakova T.A., Balakin V.E., Rozanova O.M., et al. The impact of target volumes of Ehrlich ascites carcinoma irradiated with a pencil scanning beam of protons at a total dose of 60 Gy on the tumor growth and remote effects in mice. In: Eighth International Conference on radiation in various fields of research. DOI: 10.21175/RadProc.2020.05.

4. Durante M. Proton beam therapy in Europe: More centres need more research. Br. J. Cancer. 2019;120(8):777–778.

5. Rajkapoor B., Sankari M., Sumithra M., et al. Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. Biosci Biotechnol Biochem. 2007;71(9):2177–2183. DOI: 10.1271/bbb.70149.

6. Smith J., van den Broek F., Martorell J., et al. Principles and practice in ethical review of animal experiments across Europe: Summary of the report of the FELASA working group on ethical evaluation of animal experiments. Laboratory Animals. 2007;41(2):143–160.

7. Sorensen B.S., Horsman M.R., Alsner J., et al. Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model. Acta Oncol. 2015;54(9):1623–1630. DOI: 10.3109/0284186X.2015.1069890.


Review

For citations:


Balakin V.E., Belyakova T.A., Rozanova O.M., Smirnova E.N., Shemyakov A.E., Strelnikova N.S. Study of early and remote effects of hypofractionated proton irradiation in a model of solid Ehrlich ascites carcinoma in mice. Journal Biomed. 2021;17(3E):127-132. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-127-132

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ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)