Succinate-containing drugs in the correction of morphofunctional disorders of the liver and metabolism in experimental cirrhosis
https://doi.org/10.33647/2713-0428-17-3E-165-169
Abstract
In experiments on 55 rats, the effect of the administration of succinic acid on the morpho-functional state of the liver and metabolism in experimental liver cirrhosis caused by prolonged administration (within 3 weeks) of acetaminophen in combination with a high-fat diet was evaluated. Daily administration of succinic acid at a dose of 50 mg/kg for 2 weeks led to the disappearance of cholestatic syndrome, restoration of pigment metabolism parameters, and normalization of liver cytoarchitectonics. Thus, succinic acid as a basis for succinate-containing drugs is an effective hepatoprotector in the metabolic treatment of liver cirrhosis.
About the Authors
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department;
Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Dr. Sci. (Biol.), 129090, Moscow, Bolshaya Sukharevskaya Square, 3;
125993, Moscow, Volokolamskoe Highway, 4
Yu. V. Gurman
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
Russian Federation
Russian Federation
129090, Moscow, Bolshaya Sukharevskaya Square, 3
E. A. Kislyakova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
129090, Moscow, Bolshaya Sukharevskaya Square, 3
I. G. Vilkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
Russian Federation
Russian Federation
129090, Moscow, Bolshaya Sukharevskaya Square, 3
E. V. Klychnikova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
Russian Federation
Russian Federation
Cand. Sci. (Med.),
129090, Moscow, Bolshaya Sukharevskaya Square, 3
V. N. Baymatov
Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Scryabin
Russian Federation
Russian Federation
Dr. Sci. (Vet.), Prof.,
109472, Moscow, Academika Scryabina Str., 23
T. S. Popova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Сare Department
Russian Federation
Russian Federation
Dr. Sci. (Biol.), Prof.,
129090, Moscow, Bolshaya Sukharevskaya Square, 3
References
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2. Tropskaya N.S., KislyakovaE.A., Vilkova I.G., et al. Eksperimental’naya model’ tsirroza pecheni [Experimental model ofliver cirrhosis]. Bulletin of Experimental Biology and Medicine. 2019;3:391– 396. (In Russian).
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Review
For citations:
Tropskaya N.S., Gurman Yu.V., Kislyakova E.A., Vilkova I.G., Klychnikova E.V., Baymatov V.N., Popova T.S. Succinate-containing drugs in the correction of morphofunctional disorders of the liver and metabolism in experimental cirrhosis. Journal Biomed. 2021;17(3):165-169. (In Russ.) https://doi.org/10.33647/2713-0428-17-3E-165-169
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