ANTI-IDIOTYPIC MONOCLONAL ANTIBODIES AGAINST MORPHINE: PRODUCTION, PROPERTIES AND PROSPECTS OF USE
https://doi.org/10.33647/2074-5982-15-2-63-68
Abstract
This paper describes a technique for producing anti-idiotypic monoclonal antibodies (Ab2) against two morphine derivatives. The specificity of the obtained antibodies was investigated using enzyme immunoassay. The biological activity of the antibodies was studied using an in-vitro model of human glioblastoma T98G cell line prolifer ation.
About the Authors
A. V. Trofimov
State Research Institute of Highly Pure Biopreparations of the Federal Medical and Biological Agency of Russia
Russian Federation
197110, Russian Federation, Saint Petersburg, Pudozhskaya str., 7
Russian Federation
197110, Russian Federation, Saint Petersburg, Pudozhskaya str., 7
A. Ya. Rak
State Research Institute of Highly Pure Biopreparations of the Federal Medical and Biological Agency of Russia
Russian Federation
197110, Russian Federation, Saint Petersburg, Pudozhskaya str., 7
Russian Federation
197110, Russian Federation, Saint Petersburg, Pudozhskaya str., 7
A. G. Berzina
V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119034, Russian Federation, Moscow, Kropotkinskiy lane, 23
L. I. Ulyanova
V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
Russian Federation
Russian Federation
Dr. Sci. (Biol.),
119034, Russian Federation, Moscow, Kropotkinskiy lane, 23
N. V. Gamaleya
V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
119034, Russian Federation, Moscow, Kropotkinskiy lane, 23
T. A. Klimova
V. Serbsky Federal Medical Research Centre for Psychiatry and Narcology
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119034, Russian Federation, Moscow, Kropotkinskiy lane, 23
N. V. Stankova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
143442, Russian Federation, Moscow region, Krasnogorsk district, Settlement Svetlye Gory, building 1
References
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5.
Review
For citations:
Trofimov A.V., Rak A.Ya., Berzina A.G., Ulyanova L.I., Gamaleya N.V., Klimova T.A., Stankova N.V. ANTI-IDIOTYPIC MONOCLONAL ANTIBODIES AGAINST MORPHINE: PRODUCTION, PROPERTIES AND PROSPECTS OF USE. Journal Biomed. 2019;(2):63-68. (In Russ.) https://doi.org/10.33647/2074-5982-15-2-63-68
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