The Effect of GABA on the Gut Microbiota During Metabolic Stress
https://doi.org/10.33647/2074-5982-18-3-10-13
Abstract
The effect of gamma-aminobutyric acid (GABA) on the gut microbiota was evaluated in experiments on 47 rats with metabolic stress (MS) induced by food deprivation. MS was found to be associated with changes in the qualitative and quantitative composition of the caecum microbiota, including the redistribution of opportunistic flora, the growth of pathogenic microorganisms, as well as a decreased number of lactobacilli and bifidobacteria. Daily administration of GABA at a dose of 70 mg/kg during MS led to a decrease in the number of pathogens, thus leading to the restoration of normal eubionts in the cecum.
About the Authors
Yu. V. Gurman
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Yulia V. Gurman.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliya S. Tropskaya - Dr. Sci. (Biol.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University).
129090, Moscow, Bolshaya Sukharevskaya Square, 3; 125993, Moscow, Volokolamskoe Highway, 4.
T. V. Chernen'kaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tatyana V. Chernen'kaya - Cand. Sci. (Med.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
T. S. Popova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tamara S. Popova - Dr. Sci. (Biol.), Prof., N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
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Review
For citations:
Gurman Yu.V., Tropskaya N.S., Chernen'kaya T.V., Popova T.S. The Effect of GABA on the Gut Microbiota During Metabolic Stress. Journal Biomed. 2022;18(3):10-13. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-10-13
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