A New Diagnostic Approach to Assessing Tissue Changes in Type 2 Diabetes Mellitus in Mice Using “LASMA ST” Device
https://doi.org/10.33647/2074-5982-18-3-37-44
Abstract
For the first time, LASMA ST, a device for laser diagnostic, was adapted for preclinical studies on laboratory db/db mouse genetic models of type 2 diabetes. The proposed method for studying of tissue changes during diabetes mellitus consists in a simultaneous control of microcirculation compartments: blood and lymph flow and oxidative coenzymes. The presented approach is characterized by a high informational value, safety and objectivity, as well as by the possibility of dynamic monitoring and obtaining online data on tissue metabolism (reduced nicotinamide adenine dinucleotide - NADH and oxidized flavin adenine dinucleotide - FAD).
About the Authors
O. I. Stepanova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga I. Stepanova - Cand. Sci. (Biol.), Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
R. A. Klesov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Roman A. Klesov.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
Kh. Kh. Semenov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Khyzyr Kh. Semenov - Cand. Sci. (Biol.), Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
I. A. Pomytkin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Igor A. Pomytkin - Cand. Sci. (Chem.), Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
V. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vladislav N. Karkischenko - Dr. Sci. (Med.), Prof., Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
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Review
For citations:
Stepanova O.I., Klesov R.A., Semenov Kh.Kh., Pomytkin I.A., Karkischenko V.N. A New Diagnostic Approach to Assessing Tissue Changes in Type 2 Diabetes Mellitus in Mice Using “LASMA ST” Device. Journal Biomed. 2022;18(3):37-44. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-37-44
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