Disorders in the Functional State of the Central Nervous System, Intestinal Peristalsis and Microbiocenosis in Experimental Barbiturate Poisoning
https://doi.org/10.33647/2074-5982-18-3-45-49
Abstract
Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated the absence or weakening of reflexes at the levels of the spinal cord, medulla oblongata, bridge and midbrain and cerebral cortex over the period of one day. Other signs included a pronounced hypothermia, a decrease in the respiratory rate and a violation of its rhythm, a distinct tendency to bradycardia. On days 1-3 after the administration of sodium thiopental, a restoration of the respiratory rate, heart rate, body temperature, and the functional state of the central nervous system at various levels was observed, with the exception of the cerebral cortex. In the long term, following the administration of sodium thiopental for up to 21 days, a depression of the functional state of the central nervous system at the level of the cerebral cortex, violation of coordinated propulsive peristalsis of the small intestine and intestinal microbiocenosis were detected. Hence, in experimentally simulated barbiturate poisoning, not only is the suppression of the functions of the central nervous system observed, but also significant and prolonged restructuring of the functional state of the gastrointestinal tract.
About the Authors
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliya S. Tropskaya - Dr. Sci. (Biol.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University).
129090, Moscow, Bolshaya Sukharevskaya Square, 3; 125993, Moscow, Volokolamskoe Highway, 4.
E. A. Kislyakova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Ekaterina A. Kislyakova - Cand. Sci. (Biol.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
I. G. Vilkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Irina G. Vilkova.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
Yu. V. Gurman
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Yulia V. Gurman.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
O. S. Kislitsyna
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Oksana S. Kislitsyna.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
A. V. Zerebtzov
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Alexey V. Zerebtzov.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
Ye. N. Borodina
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Yevgeniya N. Borodina.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
T. V. Chernen'kaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tatyana V. Chernen'kaya - Cand. Sci. (Med.), N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
T. S. Popova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Tamara S. Popova - Dr. Sci. (Biol.), Prof., N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department.
129090, Moscow, Bolshaya Sukharevskaya Square, 3.
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Review
For citations:
Tropskaya N.S., Kislyakova E.A., Vilkova I.G., Gurman Yu.V., Kislitsyna O.S., Zerebtzov A.V., Borodina Ye.N., Chernen'kaya T.V., Popova T.S. Disorders in the Functional State of the Central Nervous System, Intestinal Peristalsis and Microbiocenosis in Experimental Barbiturate Poisoning. Journal Biomed. 2022;18(3):45-49. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-45-49
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