Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis
https://doi.org/10.33647/2074-5982-18-3-50-57
Abstract
This research was aimed at creating novel domestic medical preparations with a modified release of active peptide substances obtained from renewable sources of biological materials. These preparations can be used for the purposes of pharmacological correction of desynchronosis by the action of biologically active substances on the processes of lipid peroxidation and antioxidant protection of cells in order to increase the body's resistance to the negative effects of various stress factors. The conducted studies have confirmed the efficacy of modified-release peptide extracts when correcting the body's oxidative status in various types of desynchronosis.
Keywords
peptide extracts,
prolonged action,
light desynchronosis,
bioactive peptides of the epiphysis and pituitary gland,
pharmacological correction
Supporting agencies: Grant of the FSBSI SC FHHRP “Youth Project of the Year”.
About the Authors
A. V. Sharabanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Andrey V. Sharabanov.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
E. G. Batotsyrenova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova - Cand. Sci. (Biol.), Assoc. Prof., Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia.
192019, Saint Petersburg, Bekhtereva Str., 1; 194100, Saint-Petersburg, Litovskaya Str., 2.
V. A. Kashuro
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia
Russian Federation
Russian Federation
Vadim A. Kashuro - Dr. Sci. (Med.), Assoc. Prof., St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia.
194100, Saint-Petersburg, Litovskaya Str., 2; 191186, Saint Petersburg, embankment of the Moika River, 48.
M. T. Gasanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Melik T. Gasanov - Cand. Sci. (Med.), Assoc. Prof., Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia.
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1.
Yu. V. Komov
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Yurij V. Komov - Cand. Sci. (Biol.), St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia.
194100, Saint-Petersburg, Litovskaya Str., 2.
References
1. Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V., Kozlov V.K., Kovalenko A.L. Effektivnost' peptidnogo produkta iz gipofiza severnogo olenya v kachestve antioksidantnogo sredstva pri sochetannom vozdeystvii svetovogo desinkhronoza i deprimiruyushchego toksikanta [Efficacy of a reindeer pituitary peptide product as an antioxidant under combined exposure to light desynchronosis and a depriming toxicant]. Antibiotics and chemotherapy. 2021;66(7-8):20-29. (In Russian). DOI: 10.37489/0235-2990-2021-66-7-8-20-29.
2. Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V. Farmakologicheskaya korrektsiya otdalennykh posledstviy ostrogo tyazhelogo otravleniya tiopentalom natriya v usloviyakh khronicheskogo svetovogo desinkhronoza [Pharmacological correction of longterm consequences of acute severe poisoning with sodium thiopental in chronic light desynchronosis]. Biomedicina [Journal Biomed]. 2021;17(3):23-28. (In Russian). DOI: 10.33647/2074-5982-17-3-23-28.
3. Batotsyrenova E.G., Zolotoverkhaya E.A., Kashuro V.A., Sharabanov A.V. Izmenenie biokhimicheskikh pokazateley v syvorotke krovi krys pri khronicheskom svetovom desinkhronoze [Changes of biochemical parameters in blood serum rats under chronic light desynchronosis]. Biomeditsinskaya khimiya. 2020;66(6):450-455. (In Russian). DOI: 10.18097/PBMC20206606450.
4. Harder L., Oster H. Circadian rhythms — how do they influence our lives? Dtsch. Med. Wochenschr. 2019;144(15):1014-1017. DOI: 10.1055/a-0662-1950.
Review
For citations:
Sharabanov A.V., Batotsyrenova E.G., Kashuro V.A., Gasanov M.T., Komov Yu.V. Antioxidant Effects of Modified-Release Peptide Extracts in Correcting Light Desynchronosis. Journal Biomed. 2022;18(3):50-57. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-50-57
Views:
297
Email this article 
