Antimicrobial Peptides Based on Bacterial S1 Protein Sequences as a Potential Alternative to Antibiotics
https://doi.org/10.33647/2074-5982-18-3-84-89
Abstract
An original approach to the development of antimicrobial peptides (AMPs) with a new mechanism of action based on directed coaggregation of a peptide with a target protein is proposed. The unique multifunctional bacterial ribosomal protein S1 was chosen as the target protein. The amyloidogenic and antibacterial effects of various peptides synthesized on the basis of S1 ribosomal protein sequences were studied. The results obtained can serve as a basis for the creation of new AMPs against various strains of pathogenic organisms.
About the Authors
O. V. Galzitskaya
Institute of Protein Research of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Oxana V. Galzitskava - Dr. Sci. (Phys.-Math), Institute of Protein Research of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences.
142290, Moscow Region, Pushchino, Institutskaya Str., 4; 142290, Moscow Region, Pushchino, Institutskaya Str., 3.
A. V. Machulin
Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences
Russian Federation
Russian Federation
Andrev V. Machulin - Cand. Sci. (Biol.), Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences.
142290, Moscow Region, Pushchino, Nauki Ave., 5.
E. I. Deryusheva
Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Evgeniva I. Deryusheva - Cand. Sci. (Phys.-Math), Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”.
142290, Moscow Region, Pushchino, Nauki Ave., 3.
A. V. Glyakina
Institute of Protein Research of the Russian Academy of Sciences; Institute of Mathematical Problems of Biology of the Russian Academy of Sciences — Branch of “Federal Research Center Institute of Applied Mathematics named after M.V. Keldysh of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Anna V. Glyakina - Cand. Sci. (Phys.-Math), Institute of Protein Research of the Russian Academy of Sciences; Institute of Mathematical Problems of Biology of the Russian Academy of Sciences — Branch of “Federal Research Center Institute of Applied Mathematics named after M.V. Keldysh of the Russian Academy of Sciences”.
142290, Moscow Region, Pushchino, Institutskaya Str., 4; 142290, Moscow Region, Pushchino, Professora Vitkevicha Str., 1.
S. Yu. Grishin
Institute of Protein Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sergei Yu. Grishin.
142290, Moscow Region, Pushchino, Institutskaya Str., 4.
S. R. Kurpe
Institute of Protein Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Stanislav R. Kurpe.
142290, Moscow Region, Pushchino, Institutskaya Str., 4.
A. V. Panfilov
Institute of Protein Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alexander V. Panfilov.
142290, Moscow Region, Pushchino, Institutskaya Str., 4.
P. A. Domnin
National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of Russia; Lomonosov Moscow State University
Russian Federation
Russian Federation
Pavel A. Domnin.
123098, Moscow, Gamalei Str., 18; 119991, Moscow, Leninskie Gory Str., 1.
S. V. Kravchenko
Institute of Environmental and Agricultural Biology (X-BIO), Tyumen State University
Russian Federation
Russian Federation
Sergey V. Kravchenko.
625003, Tyumen, Lenina Str., 25.
S. A. Ermolaeva
National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Svetlana A. Ermolaeva - Dr. Sci. (Biol.), National Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health Care of Russia.
123098, Moscow, Gamalei Str., 18.
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Review
For citations:
Galzitskaya O.V., Machulin A.V., Deryusheva E.I., Glyakina A.V., Grishin S.Yu., Kurpe S.R., Panfilov A.V., Domnin P.A., Kravchenko S.V., Ermolaeva S.A. Antimicrobial Peptides Based on Bacterial S1 Protein Sequences as a Potential Alternative to Antibiotics. Journal Biomed. 2022;18(3):84-89. (In Russ.) https://doi.org/10.33647/2074-5982-18-3-84-89
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