SEARCH FOR NEW OLIGOPEPTIDE MOLECULES FOR PHARMACOLOGICAL CORRECTION OF NSAIDS-INDUCED GASTRIC ULCER
https://doi.org/10.33647/2074-5982-15-3-90-97
Abstract
This article presents the results of a study aimed at determining the gastroprotective activity of a number of short-chain peptides against the background of experimental gastropathy in rats. Indomethacin ulcer was used as a model of ulceration. Omeprazole, a drug of basic therapy, was used as a comparison drug. According to the results of the study, two peptides — tetrapeptide LA-4 and hexapeptide LF-6 — demonstrated the gastroprotective activity. The effect was manifested in a signifi cant decrease in the average number of erosions on the surface of the gastric mucosa, their depth, the number of stripe-shaped erosions and Paul’s Index. At the same time, the LF-6 peptide had an effect comparable to that of omeprazole, which makes it promising and interesting for further study.
About the Authors
A. Yu. Zharikov
Altai State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Biol.), Assoc. Prof.,
656038, Altai Krai, Barnaul, Lenina avenue, 40
S. E. Lorents
Altai State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
656038, Altai Krai, Barnaul, Lenina avenue, 40
Russian Federation
656038, Altai Krai, Barnaul, Lenina avenue, 40
I. P. Bobrov
Altai State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
656038, Altai Krai, Barnaul, Lenina avenue, 40
O. N. Mazko
Altai State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
656038, Altai Krai, Barnaul, Lenina avenue, 40
O. G. Makarova
Altai State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Cand. Sci. (Pharm.),
656038, Altai Krai, Barnaul, Lenina avenue, 40
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Review
For citations:
Zharikov A.Yu., Lorents S.E., Bobrov I.P., Mazko O.N., Makarova O.G. SEARCH FOR NEW OLIGOPEPTIDE MOLECULES FOR PHARMACOLOGICAL CORRECTION OF NSAIDS-INDUCED GASTRIC ULCER. Journal Biomed. 2019;(3):90-97. (In Russ.) https://doi.org/10.33647/2074-5982-15-3-90-97
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