Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats
https://doi.org/10.33647/2074-5982-19-3-58-65
Abstract
The central mechanisms of acetylcholine and insulin in nanoparticles via transpalatinal administration to cats were studied using a neuroimaging algorithm, including a software-supported pharmaco-EEG analysis of graphic functions of normalized electrograms. The studied substances were found to exhibit a predominantly depressing action, which begins in the first hours after administration. Liposomal forms of acetylcholine and insulin penetrate the blood-brain barrier and modulate the intracentral relations of the brain, reflected in high-frequency rhythms (mainly γ-rhythms) of the hippocampal region of the brain and associated with the activity of intercalary neurons and pyramidal cells. The substances under study appear to be promising for the prevention and treatment of neuropathies caused, e.g., by geriatric dysfunctions of the cholinergic and insulin signaling systems, as well as for improving memory consolidation and cognitive functions.
About the Authors
Yu. V. Fokin
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Yuriy V. Fokin, Cand. Sci. (Biol.)
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
S. Yu. Kharitonov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Sergey Yu. Kharitonov
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
L. A. Taboyakova
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Lidiya A. Taboyakova
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
N. N. Karkischenko
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Nikolay N. Karkischenko, Dr. Sci. (Med.), Prof., Academician of the Russian Academy of Rocket and Artillery Sciences, Corresponding Member of the Russian Academy of Sciences
143442, Moscow Region, Krasnogorsk District, Svetlye Gory Village, 1
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Review
For citations:
Fokin Yu.V., Kharitonov S.Yu., Taboyakova L.A., Karkischenko N.N. Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats. Journal Biomed. 2023;19(3):58-65. (In Russ.) https://doi.org/10.33647/2074-5982-19-3-58-65
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