Neuromuscular Joint Function Impairment in Leptin-Resistant Mice
https://doi.org/10.33647/2074-5982-19-3-77-81
Abstract
The study was aimed at exploring and describing the main parameters of neuromuscular joint function in young adult leptin-resistant C57Bl/Ks-db+/+m (db/db) mice. The experiment was carried out on 10 4-month-old male db/db mice and 10 male wild-type control mice, using stimulation electroneuromyography to assess M-wave parameters for m. gastrocnemius and m. biceps brachii. We discovered a decrease in maximal amplitudes along with an increase in the M-wave latency and duration, indicating the presence of combined axonal and demyelinating peripheral nerve injury.
About the Authors
V. A. Prikhodko
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia ; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Veronika A. Prikhodko
197376, St. Petersburg, Professor Popov Str., 14A
197376, Saint Petersburg, Akad. Pavlova Str., 12A
T. M. Matuzok
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia ; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Матузок Татьяна Максимовна
197376, St. Petersburg, Professor Popov Str., 14A
197376, Saint Petersburg, Akad. Pavlova Str., 12A
S. V. Okovityi
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health Care of Russia ; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sergey V. Okovityi, Dr. Sci. (Med.), Prof.
197376, St. Petersburg, Professor Popov Str., 14A
197376, Saint Petersburg, Akad. Pavlova Str., 12A
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Review
For citations:
Prikhodko V.A., Matuzok T.M., Okovityi S.V. Neuromuscular Joint Function Impairment in Leptin-Resistant Mice. Journal Biomed. 2023;19(3):77-81. (In Russ.) https://doi.org/10.33647/2074-5982-19-3-77-81
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