3D Printing of a Tissue-Engineered Structure Intended to Replace Cartilage Defects
https://doi.org/10.33647/2713-0428-19-3E-52-58
Abstract
This article describes the process of developing a tissue-engineered structure that meets the biocompatibility and biodegradation parameters necessary for replacing cartilage tissue defects. The study was carried out using 3D bioprinting technology, which represents a promising research direction in the biomedical field. It is known that, due to the specifics of its structure, cartilage tissue is not capable of complete regeneration of damage. The methods currently used for treating arthrosis are associated with a number of limitations and disadvantages, which makes research aimed at developing alternative methods for arthrosis treatment particularly relevant. The development of tissue-engineered structures by 3D bioprinting requires the materials not only certified for medical use but also exhibiting biocompatibility and biodegradation properties. Polylactide (PLA) and sodium alginate satisfy the above requirements; moreover, their availability and economic affordability make them one of the most popular materials for 3D bioprinting.
About the Authors
S. A. Machulin
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Semen A. Machulin
123182, Moscow, Zhivopisnaya Str., 46
T. A. Astrelina
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Tatiana A. Astrelina - Dr. Sci. (Med.), Prof.
123182, Moscow, Zhivopisnaya Str., 46
D. Yu. Usupzhanova
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Daria Yu. Usupzhanova - Cand. Sci. (Biol.).
123182, Moscow, Zhivopisnaya Str., 46
A. O. Zavialov
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anton O. Zavialov
123182, Moscow, Zhivopisnaya Str., 46
T. F. Malivanova
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Tatiana F. Malivanova - Cand. Sci. (Med.)
123182, Moscow, Zhivopisnaya Str., 46
А. I. Golovkova
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anastasia I. Golovkova
123182, Moscow, Zhivopisnaya Str., 46
I. V. Kobzeva
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Irina V. Kobzeva - Cand. Sci. (Med.).
123182, Moscow, Zhivopisnaya Str., 46
Yu. B. Suchkova
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Yulia B. Suchkova - Cand. Sci. (Med.).
123182, Moscow, Zhivopisnaya Str., 46
V. A. Brunchukov
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Vitaliy A. Brunchukov
123182, Moscow, Zhivopisnaya Str., 46
A. A. Rastorgueva
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Anna A. Rastorgueva
123182, Moscow, Zhivopisnaya Str., 46
V. А. Nikitina
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Viktoria A. Nikitina
123182, Moscow, Zhivopisnaya Str., 46
E. E. Lomonosova
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Elena E. Lomonosova
123182, Moscow, Zhivopisnaya Str., 46
O. G. Mihadarkina
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga G. Mihadarkina
123182, Moscow, Zhivopisnaya Str., 46
A. S. Samoilov
State Scientific Center of the Russian Federation — Federal Medical Biophysical Center named after A.I. Burnazyan of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alexandr S. Samoilov - Dr. Sci. (Med.), Corr. Member of the RAS, Prof. of the RAS.
123182, Moscow, Zhivopisnaya Str., 46
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Review
For citations:
Machulin S.A., Astrelina T.A., Usupzhanova D.Yu., Zavialov A.O., Malivanova T.F., Golovkova А.I., Kobzeva I.V., Suchkova Yu.B., Brunchukov V.A., Rastorgueva A.A., Nikitina V.А., Lomonosova E.E., Mihadarkina O.G., Samoilov A.S. 3D Printing of a Tissue-Engineered Structure Intended to Replace Cartilage Defects. Journal Biomed. 2023;19(3E):52-58. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-52-58
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