Preview

Journal Biomed

Advanced search

Influence of a Nanoform of 9-phenyl-2,3,4,5,6,7,8,9-octahydro-1H-selenoxanthene on the Reproductive Function of White Rats

https://doi.org/10.33647/2713-0428-19-3E-85-89

Abstract

Despite the diversity of modern treatment methods, infertility rates remain high both in Russian and globally. In the present experimental study, we study the effect of a nanopreparation based on a selenoxanthene derivative and cyclodextrin on the reproduction of white outbred rats (females) after the administration of mifepristone. Selenoxanthene at a dose of 0.35 mg/kg and 0.7 mg/kg intragastrically for 5 days increased the reproductive activity of animals.

About the Authors

O. V. Buyuklinskayа
St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation

Olga V. Buyuklinskaya - Dr. Sci. (Med.), Assoc. Prof.

197376, St. Petersburg, Professora Popova str., 14, lit. A



S. M. Napalkova
St. Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia
Russian Federation

Svetlana M. Napalkova - Dr. Sci. (Biol.), Prof.

197376, St. Petersburg, Professora Popova str., 14, lit. A



E. D. Kubasova
Northern State Medical University of the Ministry of Health Care of Russia
Russian Federation

Elena D. Kubasova - Cand. Sci. (Biol.).

163000, Arkhangelsk, Troitskiy Ave., 51



D. S. Makarova
Maksavit
Russian Federation

Daria S. Makarova – Maksavit.

163001, Arkhangelsk, Troitskiy Ave., 121/3



References

1. Darzhaev Z.Yu. Chastota besplodiya v brake sredi gorodskogo i sel'skogo naseleniya Respubliki Buryatiya: rezul'taty populyatsionnogo issledovaniya [The frequency of infertility in marriage among the urban and rural population of the Republic of Buryatia: results of a population study]. Fundamental and clinical medicine. 2017;2(4):14–21. (In Russian).

2. Shikh E.V., Makhova A.A., Eremenko N.N. Polinenasyshchennyye zhirnyye kisloty i selen kak neobkhodimyye komponenty mikronutriyentnoy podderzhki v period beremennosti [Polyunsaturated fatty acids and selenium as necessary components of micronutrient support during pregnancy]. RMZH. Mat' i ditya [Russian Medical Journal. Mother and child]. 2017;2:126–131. (In Russian).

3. Shurygina I.A., Dremina N.N., Trukhan I.S., Shurygin M.G. Selen v nanoforme: toksichnost' i bezopasnost'. [Selenium in nanoform: toxicity and safety]. Baykal'skiy meditsinskiy zhurnal [Baikal Medical Journal.] 2022;1(1):24–32. (In Russian). DOI: 10.57256/2949-0715-20221-1-24-32.

4. Ayeleke R.O., Brown J., Lam W.S., Broekmans F.J. Gonadotrophin-releasing hormone antagonists for assisted reproductive technology. Cochrane database Syst. Rev. 2016;4:CD001750.

5. Yen C.F., Kim M.R., Lee C.L. Epidemiologic Factors Associated with Endometriosis in East Asia. Gynecol. Minim. Invasive Ther. 2019;8(1):4–11. DOI: 10.4103/GMIT.GMIT_83_18.


Review

For citations:


Buyuklinskayа O.V., Napalkova S.M., Kubasova E.D., Makarova D.S. Influence of a Nanoform of 9-phenyl-2,3,4,5,6,7,8,9-octahydro-1H-selenoxanthene on the Reproductive Function of White Rats. Journal Biomed. 2023;19(3E):85-89. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-85-89

Views: 462


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)