GLYPROLINE PEPTIDE PHARMACODYNAMICS IN RATS IN THE SETTING OF METABOLIC SYNDROME BY THE PARAMETERS OF LIPID METABOLISM AND TROMBOELASTOGRAMMA
https://doi.org/10.33647/2074-5982-15-4-58-66
Abstract
In this study, experimental data on the biological action of glyproline peptides — Pro-Gly-Pro, Pro-ArgPro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu — on the processes of blood coagulation and lipid metabolism were obtained using animal models of metabolic syndrome. Under the conditions of increased blood clotting and hypercholesterolemia, the regulatory peptides under study were administered intranasally for 7 days once every 24 hours. 20 hours after the last peptide administration, thromboelastogram parameters confi rmed the restoration of the functional state of the coagulating and anticoagulant systems. In addition, a simultaneous positive shift in the parameters of lipid metabolism was observed. These changes lasted for 7 days following the withdrawal of the drugs. It is found that the biological action of the peptides under study consists in their simultaneous regulatory impact on the processes of hemostasis and lipid metabolism.
About the Authors
T. Yu. Obergan
Lomonosov Moscow State University
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119234, Moscow, Leninskie gory str., 1/12
M. G. Lyapina
Lomonosov Moscow State University
Russian Federation
119234, Moscow, Leninskie gory str., 1/12
Russian Federation
119234, Moscow, Leninskie gory str., 1/12
M. E. Grigorjeva
Lomonosov Moscow State University
Russian Federation
Russian Federation
Cand. Sci. (Biol.),
119234, Moscow, Leninskie gory str., 1/12
L. A. Lyapina
Lomonosov Moscow State University
Russian Federation
119234, Moscow, Leninskie gory str., 1/12
Russian Federation
119234, Moscow, Leninskie gory str., 1/12
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For citations:
Obergan T.Yu., Lyapina M.G., Grigorjeva M.E., Lyapina L.A. GLYPROLINE PEPTIDE PHARMACODYNAMICS IN RATS IN THE SETTING OF METABOLIC SYNDROME BY THE PARAMETERS OF LIPID METABOLISM AND TROMBOELASTOGRAMMA. Journal Biomed. 2019;(4):58-66. (In Russ.) https://doi.org/10.33647/2074-5982-15-4-58-66
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