Effect of L-thyroxine, a Human Serum Albumin Natural Ligand, on the Kinetics of β-amyloid Peptide Fibril Formation
https://doi.org/10.33647/2713-0428-19-3E-114-118
Abstract
Ligands of human serum albumin (HSA) are capable of modulating its interaction with β-amyloid peptide (Aβ), which is a key factor in the pathogenesis of Alzheimer’s disease (AD). L-thyroxine (L-Tr), a natural HSA ligand, is associated with the pathogenesis of AD according to epidemiological and animal model studies. In this work, we studied the kinetics of Aβ fibril formation in the presence of L-Tr and HSA using a fluorescent test with thioflavin T. L-Tr had no significant effect on the inhibitory effect of HSA on fibril growth. At the same time, L-Tr itself had an inhibitory effect similar to that of HSA. Our data can partially explain the relationship between AD and thyroid pathologies.
Supporting agencies: the research was funded by a grant from the Russian Science Foundation No. 20-74-10072
About the Authors
E. A. Litus
Institute for Biological Instrumentation of the Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina A. Litus - Cand. Sci. (Med.).
142290, Moscow Region, Pushchino, Nauki Ave., 3
E. L. Nemashkalova
Institute for Biological Instrumentation of the Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina L. Nemashkalova - Cand. Sci. (Biol.).
142290, Moscow Region, Pushchino, Nauki Ave., 3
A. A. Vologzhannikova
Institute for Biological Instrumentation of the Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alisa A. Vologzhannikova - Cand. Sci. (Biol.).
142290, Moscow Region, Pushchino, Nauki Ave., 3
E. I. Deryusheva
Institute for Biological Instrumentation of the Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences
Russian Federation
Russian Federation
Evgeniya I. Deryusheva - Cand. Sci. (Phis.-Math.).
142290, Moscow Region, Pushchino, Nauki Ave., 3
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Review
For citations:
Litus E.A., Nemashkalova E.L., Vologzhannikova A.A., Deryusheva E.I. Effect of L-thyroxine, a Human Serum Albumin Natural Ligand, on the Kinetics of β-amyloid Peptide Fibril Formation. Journal Biomed. 2023;19(3E):114-118. (In Russ.) https://doi.org/10.33647/2713-0428-19-3E-114-118
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