AMPLITUDE AND SPECTRAL ANALYSIS OF ELECTROCORRTICOGRAMS IN RATS WITH TRAUMATIC BRAIN INJURY
https://doi.org/10.33647/2074-5982-15-4-107-120
Abstract
A series of amplitude and spectral studies was performed to investigate brain cortical activity in rats with traumatized brain (open penetrating traumatic brain injury (TBI)). Electrocorticograms (ECoG) were recorded on the 3rd and the 7th day following the trauma. An amplitude analysis comprised an estimation of the mean signal amplitude and the degree of Lempel — Ziv compression. A spectral analysis involved a calculation of the mean amplitude and δ-, θ-, α- and β-rhythm indices. Characteristic changes in the ECoG amplitude and spectral parameters were revealed in TBI rats. Traumatized animals demonstrated decreased values of both the mean signal amplitude, as well as the amplitudes and indices of θ-, α- and β-rhythms. At the same time, the mean amplitude and the index of delta-frequency were increased. Similar changes were observed not only near the traumatized area but also in the other brain cortex regions on the 3rd and 7th day following the trauma. The obtained results demonstrate that the investigated TBI model has numerous electro physiological similarities with traumas in clinical practice, thus being applicable for neurophysiological and pharmacological studies.
About the Authors
Yu. I. Sysoev
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation;
Institute of Translational Biomedicine of the Saint-Petersburg State University
Russian Federation
Russian Federation
197376, Saint Petersburg, Professora Popova str., 14А;
199034, Saint Petersburg, Universitetskaya embankment, 7–9
K. A. Kroshkina
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation
Russian Federation
197376, Saint Petersburg, Professora Popova str., 14А
Russian Federation
197376, Saint Petersburg, Professora Popova str., 14А
V. A. P’yankova
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation
Russian Federation
197376, Saint Petersburg, Professora Popova str., 14А
Russian Federation
197376, Saint Petersburg, Professora Popova str., 14А
V. E. Karev
Pediatric Research and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency
Russian Federation
Russian Federation
Cand. Sci. (Med.),
197376, Saint Petersburg, Professora Popova str., 9
S. V. Okovitiy
Saint Petersburg State Chemical Pharmaceutical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
197376, Saint Petersburg, Professora Popova str., 14А
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Review
For citations:
Sysoev Yu.I., Kroshkina K.A., P’yankova V.A., Karev V.E., Okovitiy S.V. AMPLITUDE AND SPECTRAL ANALYSIS OF ELECTROCORRTICOGRAMS IN RATS WITH TRAUMATIC BRAIN INJURY. Journal Biomed. 2019;(4):107-120. (In Russ.) https://doi.org/10.33647/2074-5982-15-4-107-120
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