Modified Effect of Peptide Preparations on Spontaneous Motor Activity in Male Rats under the Conditions of Light Desynchronosis
https://doi.org/10.33647/2074-5982-20-1-33-42
Abstract
This study examined the effect of peptide extracts from the epiphysis-pituitary gland of Reindeer (Rangifer tarandus) and a delta sleep-inducing peptide, simulating a modified release of drugs, on the spontaneous motor activity of male rats under the conditions of light desynchronosis. The study revealed changes in spontaneous motor activity under the influence of extracts of a peptide nature and a delta sleep-inducing peptide under the following polar light regimes. Under the conditions of constant lighting and constant darkness, an increase and a decrease in activity was observed, respectively. Under normal lighting, peptide extracts showed increased efficacy. This method of pharmacological adjustment of the body’s circadian oscillators using modified-release peptides can be used to develop a scheme for correcting light desynchronosis.
About the Authors
A. V. Sharabanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Andrey V. Sharabanov
143442, Moscow Region, Krasnogorsk district, Svetlye gory Village, 1
E. G. Batotsyrenova
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia; St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova, Cand. Sci. (Biol.), Assoc. Prof.
192019, Saint Petersburg, Bekhtereva Str., 1
194100, Saint Petersburg, Litovskaya Str., 2
V. A. Kashuro
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia; Herzen State Pedagogical University of Russia; Saint Petersburg State University
Russian Federation
Russian Federation
Vadim A. Kashuro, Dr. Sci. (Med.), Assoc. Prof.
194100, Saint Petersburg, Litovskaya Str., 2
191186, Saint Petersburg, Moika River Embankment, 48
199034, Saint Petersburg, University Embankment, 7/9
M. T. Gasanov
Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Melik T. Gasanov, Cand. Sci. (Med.), Assoc. Prof.
143442, Moscow Region, Krasnogorsk district, Svetlye gory Village, 1
N. V. Kuzmina
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Natalya V. Kuzmina, Cand. Sci. (Chem.)
194100, Saint Petersburg, Litovskaya Str., 2
K. M. Shchepetkova
St. Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Kristina M. Shchepetkova
194100, Saint Petersburg, Litovskaya Str., 2
References
1. Batotsyrenova E.G., Kashuro V.A., Sharabanov A.V., Kozlov V.K., Kovalenko A.L. Effektivnost' peptidnogo produkta iz gipofiza severnogo olenya v kachestve antioksidantnogo sredstva pri sochetannom vozdejstvii svetovogo desinhronoza i deprimiruyushchego toksikanta [The effectiveness of a peptide product from the pituitary gland of reindeer as an antioxidant agent under the combined effects of light desynchronosis and a depressant toxicant]. Antibiotics and chemotherapy. 2021;66(7–8):20–29. (In Russian). doi: 10.37489/0235-2990-2021-66-7-8-20-29.
2. Batotsyrenova E.G., Melnikova M.V., Belskaya A.V., Ivanov D.O., Kashuro V.A., Krasnikova E.N., Sharabanov A.V. Vliyanie peptidnogo ekstrakta iz gipofiza Severnogo olenya na kognitivnye funkcii krys pri izmenenii svetovogo rezhima [The effect of a peptide extract from the pituitary gland of Reindeer on the cognitive functions of rats when changing the light regime]. Pediatrician. 2023;14(3):87–96. (In Russian). doi: 10.17816/PED14387-96.
3. Beritashvili I.S. Pamyat' pozvonochnyh zhivotnyh, ee harakteristika i proiskhozhdenie Memory of vertebrates, its characteristics and origin. Moscow: Nauka Publ., 1974:186. (In Russian).
4. Krushinsky L.V. Biologicheskie osnovy rassudochnoj deyatel'nosti [Biological foundations of rational activity]. Moscow: MGU Publ., 1986:271.
5. Sharabanov A.V., Batotsyrenova E.G., Kashuro V.A., Gasanov M.T., Komov Yu.V. Antioksidantnyj effekt ekstraktov peptidnoj prirody s modificirovannym vysvobozhdeniem pri svetovom desinhronoze [Antioxidant effect of peptide extracts with modified release in light desynchronosis]. Biomedicina [Journal Biomed. 2022;18(3):50–57. doi: 10.33647/20745982-18-3-50-57.
6. Hazlerigg D., Blix A.S., Stokkan K.A. Waiting for the Sun: the circannual programme of reindeer is delayed by the recurrence of rhythmical melatonin secretion after the arctic night. J. Exp. Biol. 2017;220(Pt 21):3869–3872. doi: 10.1242/jeb.163741.
7. Nelson R.J., Chbeir S. Dark matters: effects of light at night on metabolism. Proc. Nutr. Soc. 2018;77(3):223– 229. doi: 10.1017/S0029665118000198.
8. Osikov M.V., Ogneva O.I. Relationship between the change of ethological status and concentration of certain cytokines in blood in experimental desynchronosis under led lighting. Pathol. Physiol. Exp. Ter. 2016;60(4):93–100.
9. Vasey C., McBride J., Penta K. Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin. Nutrients. 2021;13(10):3480. doi: 10.3390/ nu13103480.
10. Westneat D.F., Potts L.J., Sasser K.L., Shaffer J.D. Causes and Consequences of Phenotypic Plasticity in Complex Environments. Trends Ecol. Evol. 2019;34(6):555–568. doi: 10.1016/j.tree.2019.02.010.
Review
For citations:
Sharabanov A.V., Batotsyrenova E.G., Kashuro V.A., Gasanov M.T., Kuzmina N.V., Shchepetkova K.M. Modified Effect of Peptide Preparations on Spontaneous Motor Activity in Male Rats under the Conditions of Light Desynchronosis. Journal Biomed. 2024;20(1):33-42. (In Russ.) https://doi.org/10.33647/2074-5982-20-1-33-42
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