Morphological Changes in the Brain During Toxic Injury
https://doi.org/10.33647/2074-5982-20-3-28-31
Abstract
Toxic damage to various tissues of the body is accompanied by dystrophic and necrotic processes. The nervous system is most susceptible to the influence of exogenous substances both of a chemical and biological nature. Dystrophy is a complex pathological process, which is based on a violation of cell nutrition, leading to age-related and structural changes, as well as neurodegeneration. In toxic lesions, cell death can occur through either necrosis or apoptosis.
Supporting agencies: the work was carried out in accordance with the thematic plan of applied research work on the state assignment of the Golikov Research Clinical Center of Toxicology of the Federal Medical and Biolo- gical Agency of Russia and with the support of the state assignment of the Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences No. 075-00264-24-00.
About the Authors
O. N. Gaikova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Olga N. Gaikova, Dr. Sci. (Med.), Prof.
192019, Saint Petersburg, Bekhtereva Str., 1
A. A. Kozlov
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alexander A. Kozlov
192019, Saint Petersburg, Bekhtereva Str., 1
G. G. Katretskaya
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Galina G. Katretskaya, Cand. Sci. (Med.),
192019, Saint Petersburg, Bekhtereva Str., 1
M. V. Melnikova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Margarita V. Melnikova
192019, Saint Petersburg, Bekhtereva Str., 1
A. S. Melekhova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Alexandra S. Melekhova
192019, Saint Petersburg, Bekhtereva Str., 1
Yu. O. Sokolova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Yulia O. Sokolova, Cand. Sci. (Biol.)
192019, Saint Petersburg, Bekhtereva Str., 1
E. D. Bazhanova
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency of Russia; Sechenov Institute of Evolutionary Physiology and Bioche-mistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena D. Bazhanova, Dr. Sci. (Biol.)
192019, Saint Petersburg, Bekhtereva Str., 1
194223, Saint Petersburg, Toreza Ave., 44
References
1. Gajkova O.N., Anan'eva N.I., Zabrodskaya Yu.M. Morfologicheskie proyavleniya obshchepatologicheskih processov v nervnoj sisteme [Morphological manifestations of general pathological processes in the nervous system]. Saint Petersburg: “Ves'” Publ., 2015:158. (In Russian)].
2. Литвинцев Б.С. Неврологические нарушения при наркомании: принципы диагностики и терапии. СПб.: Военно-медицинская академия им. С.М. Кирова, 2018:167. [Litvintsev B.S. Nevrologicheskie narusheniya pri narkomanii: principy diagnostiki i terapii [Neurological disorders in drug addiction: principles of diagnosis and therapy]: Saint Petersburg: Voenno-medicinskaya akademiya imeni S.M. Kirova, 2018:167. (In Russian)].
3. Litvintsev B.S. Porazheniya nervnoj sistemy pri narkomanii [Damages of the nervous system in drug addiction]. Saint Petersburg: Voenno-medicinskaya akademiya imeni S.M. Kirova, 2018:160. (In Russian)].
4. Petrov A.N., Vojtsekhovich K.O., Melekhova A.S., Lisitskij D.S., Bel'skaya A.V., Mikhajlova M.V., Gajkova O.N. Problemy diagnostiki nejrotoksicheskih narushenij — posledstvij otravlenij veshchestvami sudorozhnogo dejstviya [Problems of diagnostics of neurotoxic disorders — the effects of convulsive substances poisoning]. Vestnik Rossijskoj voenno-medicinskoj akademii [Bulletin of the Russian Military Medical Academy]. 2017;3(59):211–217. (In Russian)].
5. Blümcke I., Thom M., Aronica E., Armstrong D.D., Vinters H.V., Palmini A., Jacques T.S., Avanzini G., Barkovich A.J., Battaglia G., Becker A., Cepeda C., Cendes F., Colombo N., Crino P., Cross J.H., Delalande O., Dubeau F., Duncan J., Guerrini R., Kahane P., Mathern G., Najm I., Ozkara C., Raybaud C., Represa A., Roper S.N., Salamon N., Schulze-Bonhage A., Tassi L., Vezzani A., Spreafico R. The clinic-pathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 2011;52(1):158–174. DOI: 10.1111/j.15281167.2010.02777.x
6. Kim S.H., Choi J. Pathological classification of focal cortical dysplasia (FCD): Personal comments for well understanding FCD classification. J. Korean Neurosurg. Soc. 2019;62(3):288–295. DOI: 10.3340/jkns.2019.0025
7. Lapato A.S., Szu J.I., Hasselmann J.P.C., Khalaj A.J., Binder D.K., Tiwari-Woodruff S.K. Chronic demyelination-induced seizures. Neuroscience. 2017;27(346):409–422. DOI: 10.1016/j.neuroscience.2017.01.035
8. McNeish B.L., Kolb N. Toxic neuropathies. Continuum (Minneap. Minn.). 2023;29(5):1444–1468. DOI: 10.1212/CON.0000000000001343
9. Moreno-García A., Kun A., Calero O., Medina M., Calero M. An overview of the role of lipofuscin in age-related neurodegeneration. Front. Neurosci. 2018;12:464. DOI: 10.3389/fnins.2018.00464
Review
For citations:
Gaikova O.N., Kozlov A.A., Katretskaya G.G., Melnikova M.V., Melekhova A.S., Sokolova Yu.O., Bazhanova E.D. Morphological Changes in the Brain During Toxic Injury. Journal Biomed. 2024;20(3):28-31. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-28-31
Views:
131
Email this article 
