In silico Analysis of the Stability of Ribosomal Protein S1 from Various Strains of the Pathogenic Microorganism Staphylococcus aureus.
https://doi.org/10.33647/2074-5982-20-3-32-36
Abstract
The pathogenic microorganism Staphylococcus aureus, one of the representatives of the staphylococcus family, is capable of developing resistance to antibiotics and antiseptics. The largest ribosomal protein, S1, from S. aureus contains four structural S1 domains, and short peptides synthesized based on its sequence have amyloidogenic and antimicrobial properties (antimicrobial peptides). In this work, in silico analysis of all available ribosomal protein S1 sequences from various S. aureus strains allowed us to identify residues that are characteristic of specific strains. Based on data from the I-Mutant service, changes in the stability of ribosomal protein S1 from various S. aureus strains were predicted. The results obtained will be used in the future for targeted mutations in the design of new antimicrobial peptides based on ribosomal protein S1.
About the Authors
O. V. Galzitskaya
Institute of Protein Research of the Russian Academy of Sciences; Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Oxana V. Galzitskaya, Dr. Sci. (Phys.-Math.)
142290, Moscow Region, Pushchino, Institutskaya Str., 4
142290, Russian Federation, Moscow Region, Pushchino, Institutskaya Str., 3
A. V. Machulin
Skryabin Institute of Biochemistry and Physiology of Microorganisms of the Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Andrey V. Machulin, Cand. Sci. (Biol.)
142290, Moscow Region, Pushchino, Nauki Ave., 5
E. I. Deryusheva
Institute of Biological Instrumentation of the Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences”
Russian Federation
Russian Federation
Evgeniya I. Deryusheva, Cand. Sci. (Phys.-Math.)
142290, Moscow Region, Pushchino, Nauki Ave., 3
References
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Review
For citations:
Galzitskaya O.V., Machulin A.V., Deryusheva E.I. In silico Analysis of the Stability of Ribosomal Protein S1 from Various Strains of the Pathogenic Microorganism Staphylococcus aureus. Journal Biomed. 2024;20(3):32-36. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-32-36
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