In vivo Study of the Anti/Prooxidant Activity of a Metal-Organic Coordination Polymer Modified with Iron Oxides and Ascorbic Acid
https://doi.org/10.33647/2074-5982-20-3-114-120
Abstract
Experiments on 39 male Wistar rats were performed. A metal-organic coordination polymer modified with iron oxide and ascorbic acid (composite) was administered intravenously to healthy rats at doses of 25 and 50 mg/kg. The anti/prooxidant activity of the composite was assessed 3 and 24 hours after administration. The composite in both doses was shown to have no significant effect on the homeostasis of prooxidants/antioxidants in the blood serum in healthy animals. In high doses, the composite enhances apoptosis of lymphocytes, which indicates its possible use as a catalyst for free radical processes for further use in biomedicine.
Keywords
metal-organic coordination polymer,
iron oxide nanoparticles,
ascorbic acid, anti/prooxidant activity,
rats
Supporting agencies: the research was carried out with financial support from the Russian Science Foundation, grant No. 22-73-10222
About the Authors
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliya S. Tropskaya*, Dr. Sci. (Biol.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
125993, Moscow, Volokolamskoe Highway, 4
E. V. Klychnikova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Elena V. Klychnikova, Cand. Sci. (Med.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
N. V. Borovkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Natal’ya V. Borovkova, Dr. Sci. (Med.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
A. K. Evseev
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Anatoly K. Evseev, Dr. Sci. (Chem.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
I. V. Goroncharovskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Irina V. Goroncharovskaya, Cand. Sci. (Chem.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
M. V. Storozheva
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Mayya V. Storozheva
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
Ye. N. Borodina
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Yevgeniya N. Borodina
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
A. A. Kochetova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department
Russian Federation
Russian Federation
Alena A. Kochetova
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
L. S. Bondarenko
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow City Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Lyubov S. Bondarenko, Cand. Sci. (Chem.)
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
125993, Moscow, Volokolamskoe Highway, 4
R. K. Baimuratova
Federal Research Center of Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Roza K. Baimuratova, Cand. Sci. (Chem.)
142432, Moscow Region, Chernogolovka, Akademika Semionova Ave., 1
G. I. Dzhardimalieva
Federal Research Center of Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Gulzhian I. Dzhardimalieva, Dr. Sci. (Chem.)
142432, Moscow Region, Chernogolovka, Akademika Semionova Ave., 1
K. A. Kydralieva
Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Kamilia A. Kydralieva, Dr. Sci. (Chem.)
125993, Moscow, Volokolamskoe Highway, 4
References
1. Cheng M., Lai C., Yang L., Zeng G., Huang D., Zhang C., Qin L., Hu L., Zhou C., Xiong W. Metalorganic frameworks for highly efficient heterogeneous Fenton-like catalysis. Coordination Chemistry Reviews. 2018;368:80–92. DOI: 10.1016/j.ccr.2018.04.012
2. Goroncharovskaya I.V., Evseev A.K., Shabanov A.K., Denisenko O., Kuzovlev A.N., Klychnikova E.V., Tazina E.V., Petrikov S.S. Electrochemical methods for assessment of polytrauma outcomes. Electroanalysis. 2021;33(2):550–557. DOI: 10.1002/elan.202060356
3. Jomova K., Valko M. Advances in metal-induced oxidative stress and human disease. Toxico- logy. 2011;283(2–3):65–87. DOI: 10.1016/j.tox.2011.03.001
4. Kim J.W., Lee J.Y., Oh M., Lee E.W. Аn integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis. Exp. Mol. Med. 2023;55(8):1620–1631. DOI: 10.1038/s12276-023-01077-y
5. Lecoeur H., Ledru E., Prevost M.-C., Gougeon M.-L. Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods. J. Immunol. Methods. 1997;209(2):111–123. DOI: 10.1016/s00221759(97)00138-5
Review
For citations:
Tropskaya N.S., Klychnikova E.V., Borovkova N.V., Evseev A.K., Goroncharovskaya I.V., Storozheva M.V., Borodina Ye.N., Kochetova A.A., Bondarenko L.S., Baimuratova R.K., Dzhardimalieva G.I., Kydralieva K.A. In vivo Study of the Anti/Prooxidant Activity of a Metal-Organic Coordination Polymer Modified with Iron Oxides and Ascorbic Acid. Journal Biomed. 2024;20(3):114-120. (In Russ.) https://doi.org/10.33647/2074-5982-20-3-114-120
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