Application of Langmuir Technology for Profiling Free Fatty Acids by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
https://doi.org/10.33647/2713-0428-20-3E-30-34
Abstract
The application of Langmuir technology for analyzing free fatty acids makes it possible to obtain monolayers consisting of barium monocarboxylates, while the characteristic isotopic distribution of barium makes it possible to simplify the identification of compounds containing this element in mass spectra. The formation of monomolecular Langmuir films directly on the surface of the matrix-assisted laser desorption/ ionization of the target, reduces and simplifies sample preparation, at the same time as increasing the sensitivity of the technique for profiling of free fatty acids in biological samples of different origin.
Supporting agencies: this work performed in the framework of State task of the Federal Medical and Biological Agency of Russia No. 388-00071-24-00 (code: 64.002.24.800).
About the Authors
A. S. Gladchuk
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia;
Institute for Analytical Instrumentation of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alexey S. Gladchuk, Cand. Sci. (Tech.)
192019, Saint Petersburg, Bekhtereva Str., 1;
198095, Saint Petersburg, Ivana Chernykh Str., 31-33A
P. N. Varioshkin
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Pavel N. Varioshkin
192019, Saint Petersburg, Bekhtereva Str., 1
E. G. Batotsyrenova
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia;
Saint Petersburg State Pediatric Medical University of the Ministry of Health Care of Russia
Russian Federation
Russian Federation
Ekaterina G. Batotsyrenova, Cand. Sci. (Biol.), Assoc. Prof.
192019, Saint Petersburg, Bekhtereva Str., 1;
194100, Saint Petersburg, Litovskaya Str., 2
Ya. K. Kalninia
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia;
Institute for Analytical Instrumentation of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yana K. Kalninia
192019, Saint Petersburg, Bekhtereva Str., 1;
198095, Saint Petersburg, Ivana Chernykh Str., 31-33A
E. A. Zolotoverkhaya
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Ekaterina A. Zolotoverkhaya, Cand. Sci. (Biol.)
192019, Saint Petersburg, Bekhtereva Str., 1
A. V. Andreeva
Golikov Research Center of Toxicology of the Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Arina V. Andreeva
192019, Saint Petersburg, Bekhtereva Str., 1
E. P. Podolskaya
Institute for Analytical Instrumentation of the Russian Academy of Sciences
Russian Federation
Russian Federation
Ekaterina P. Podolskaya, Dr. Sci. (Tech.)
198095, Saint Petersburg, Ivana Chernykh Str., 31-33A
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Review
For citations:
Gladchuk A.S., Varioshkin P.N., Batotsyrenova E.G., Kalninia Ya.K., Zolotoverkhaya E.A., Andreeva A.V., Podolskaya E.P. Application of Langmuir Technology for Profiling Free Fatty Acids by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Journal Biomed. 2024;20(3E):30-34. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-30-34
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