Biomodeling of Decompression Sickness in Rats
https://doi.org/10.33647/2713-0428-20-3E-135-139
Abstract
The study of decompression sickness in animals is an important area of research in the field of hyperbaric medicine. Decompression sickness is a serious condition that can occur in humans when there is a sudden transition from high-pressure conditions, such as when diving deep into water, to low-pressure conditions, such as when surfacing. Understanding the mechanisms of the onset and development of this disease in animals can help improve prevention and treatment methods in humans. This study examined different decompression rates during 60 and 30 min of exposure aground, determined the incidence of decompression sickness in animals and the survival rate.
About the Authors
A. V. BervinovaRussian Federation
Arina V. Bervinova
142290, Moscow Region, Pushchino, Nauki Ave., 3;
142290, Moscow Region, Pushchino, Nauki Ave., 6
V. A. Palikov
Russian Federation
Viktor A. Palikov
142290, Moscow Region, Pushchino, Nauki Ave., 3;
142290, Moscow Region, Pushchino, Nauki Ave., 6
I. A. Dyachenko
Russian Federation
Igor A. Dyachenko, Cand. Sci. (Biol.), Assoc. Prof.
142290, Moscow Region, Pushchino, Nauki Ave., 3;
142290, Moscow Region, Pushchino, Nauki Ave., 6
R. R. Amirov
Russian Federation
Rustam R. Amirov
123007, Moscow, Khoroshevskoe Highway, 76A
N. B. Pavlov
Russian Federation
Nikolay B. Pavlov, Cand. Sci. (Med.), Assoc. Prof.
123007, Moscow, Khoroshevskoe Highway, 76A
A. T. Logunov
Russian Federation
Aleksey T. Logunov
141400, Moscow Region, Khimki, Vashutinskoe Highway, 1
A. N. Murahsev
Russian Federation
Arkadiy N. Murahsev, Dr. Sci. (Biol.), Prof.
142290, Moscow Region, Pushchino, Nauki Ave., 3;
142290, Moscow Region, Pushchino, Nauki Ave., 6
References
1. Berghage T.E., Woolley J.M., Keating L.J. The probabilistic nature of decompression sickness. Undersea Biomed. 1974;1(2):189–196.
2. Butler B.D., Hills B.A. The lung as a filter for microbubbles. J. Appl. Physiol. Environ. Exerc. Physiol. 1979;47(3):537–543. DOI: 10.1152/jappl.1979.47.3.537
3. Buzzacott P., Lambrechts K., Mazur A., Wang Q., Papadopoulou V., Theron M., Balestra C., Guerrero F. A ternary model of decompression sickness in rats. Comput. Biol. Med. 2014;55:74–78. DOI: 10.1016/j.compbiomed.2014.10.012
4. Eftedal O.S., Lydersen S., Brubakk A.O. The relationship between venous gas bubbles and adverse effects of decompression after air dives. Undersea Hyperb. Med. 2007;34(2):99–105.
5. Lillo R.S., Parker E.C. Mixed-gas model for predicting decompression sickness in rats. J. Appl. Physiol. 2000;89(6):2107–2116. DOI: 10.1152/jappl.2000.89.6.2107
6. Vann R.D., Butler F.K., Mitchell S.J., Moon R.E. Decompression illness. Lancet. 2011;377(9760):153–164. DOI: 10.1016/S0140-6736(10)61085-9
Review
For citations:
Bervinova A.V., Palikov V.A., Dyachenko I.A., Amirov R.R., Pavlov N.B., Logunov A.T., Murahsev A.N. Biomodeling of Decompression Sickness in Rats. Journal Biomed. 2024;20(3E):135-139. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-135-139