Use of a Hyperoxic Heated Helium-Oxygen Mixture in an Experimental Model of Cerebral Arterial Air Embolism

V. A. Palikov; N. B. Pavlov; R. R. Amirov; A. M. Ismailova; S. O. Afanasyeva; E. S. Mikhailov; A. V. Bervinova; I. A. Dyachenko; A. T. Logunov; A. N. Murashev

doi:10.33647/2713-0428-20-3E-140-146

Use of a Hyperoxic Heated Helium-Oxygen Mixture in an Experimental Model of Cerebral Arterial Air Embolism

V. A. Palikov, N. B. Pavlov, R. R. Amirov, A. M. Ismailova, S. O. Afanasyeva, E. S. Mikhailov, A. V. Bervinova, I. A. Dyachenko, A. T. Logunov, A. N. Murashev

https://doi.org/10.33647/2713-0428-20-3E-140-146

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Abstract

Arterial gas embolism can result from complications related to medical and surgical procedures, as well as a direct entry of air into the systemic circulation due to the disruption of the alveolar-capillary barrier. Since air in the arterial circulation can lead to organ ischemia, this life-threatening pathology requires prompt intervention. In this study, we demonstrated the effectiveness of using a hyperoxic heated helium-oxygen mixture in cerebral arterial air embolism. Oxygen therapy under normobaric conditions did not affect the outcome of arterial air embolism. A continuous inhalation session for 30 min, or intermittent inhalation sessions 3 times for 5 min each, eliminated foci of ischemic stroke in rats.

Keywords

experimental model, air embolism, stroke, oxygen-helium mixture, rats

About the Authors

V. A. Palikov

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University
Russian Federation

Viktor A. Palikov

142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3

N. B. Pavlov

Institute of Medical and Biological Problems of the Russian Academy of Sciences; Special Design Bureau for Experimental Equipment at the Institute of Medical and Biological Problems of the Russian Academy of Sciences
Russian Federation

Nikolay B. Pavlov, Cand. Sci. (Med.), Assoc. Prof.

123007, Moscow, Khoroshevskoe Highway, 76A;
141400, Moscow Region, Khimki, Vashutinskoe Highway, 1

R. R. Amirov

Rustam R. Amirov

123007, Moscow, Khoroshevskoe Highway, 76A;
141400, Moscow Region, Khimki, Vashutinskoe Highway, 1

A. M. Ismailova

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation

Alina M. Ismailova

142290, Moscow Region, Pushchino, Nauki Ave., 6

S. O. Afanasyeva

Pushchino Branch of the Russian Biotechnological University
Russian Federation

Sofia O. Afanasyeva

142290, Moscow Region, Pushchino, Nauki Ave., 3

E. S. Mikhailov

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University
Russian Federation

Evgeniy S. Mikhailov

142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3

A. V. Bervinova

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University
Russian Federation

Arina V. Bervinova

142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3

I. A. Dyachenko

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University
Russian Federation

Igor A. Dyachenko, Cand. Sci. (Biol.), Assoc. Prof.

142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3

A. T. Logunov

Special Design Bureau for Experimental Equipment at the Institute of Medical and Biological Problems of the Russian Academy of Sciences
Russian Federation

Aleksey T. Logunov

141400, Moscow Region, Khimki, Vashutinskoe Highway, 1

A. N. Murashev

Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University
Russian Federation

Arkadiy N. Murashev, Dr. Sci. (Biol.), Prof.

142290, Moscow Region, Pushchino, Nauki Ave., 6;
142290, Moscow Region, Pushchino, Nauki Ave., 3

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Review

For citations:

Palikov V.A., Pavlov N.B., Amirov R.R., Ismailova A.M., Afanasyeva S.O., Mikhailov E.S., Bervinova A.V., Dyachenko I.A., Logunov A.T., Murashev A.N. Use of a Hyperoxic Heated Helium-Oxygen Mixture in an Experimental Model of Cerebral Arterial Air Embolism. Journal Biomed. 2024;20(3E):140-146. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-140-146

This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2074-5982 (Print)
ISSN 2713-0428 (Online)

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Use of a Hyperoxic Heated Helium-Oxygen Mixture in an Experimental Model of Cerebral Arterial Air Embolism

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Abstract

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About the Authors

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