Reproductive Disorders in Mothers and Offspring of Rats in Gestational Diabetes Modelled with a High-Calorie Diet in Combination with Tyloxapol
https://doi.org/10.33647/2713-0428-20-3E-191-196
Abstract
The absence of a generally accepted model of gestational diabetes makes the task of its search and development highly relevant. The conducted experiments found that a high-calorie diet in combination with tyloxapol administration in various modes in the second half of pregnancy of Wistar rats leads to impaired glucose tolerance, an increase in the level of DNA damage in the organs of offspring, and deviations in the postnatal period of development. The proposed model can be used to search for pharmacological correction of reproductive disorders in gestational diabetes.
About the Authors
K. S. Kachalov
Federal Research Center for Original and Promising Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Kirill S. Kachalov
125315, Moscow, Baltiyskaya Str., 8
A. S. Solomina
Federal Research Center for Original and Promising Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Anna S. Solomina, Cand. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
A. V. Rodina
Federal Research Center for Original and Promising Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Anastasia V. Rodina
125315, Moscow, Baltiyskaya Str., 8
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Review
For citations:
Kachalov K.S., Solomina A.S., Rodina A.V. Reproductive Disorders in Mothers and Offspring of Rats in Gestational Diabetes Modelled with a High-Calorie Diet in Combination with Tyloxapol. Journal Biomed. 2024;20(3E):191-196. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-191-196
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