Effect of Xylazine/Zoletil Anesthesia on the Survival of Mice after Exposure to Radiations with Different Values of Linear Energy Transfer
https://doi.org/10.33647/2713-0428-20-3E-216-220
Abstract
The survival of mice was determined 30 days after exposure to protons, carbon ions, or X-rays in the presence and absence of xylazine-zoletil anesthesia. The anesthesia used was shown to increase the lifespan of mice during the specified period for photons and most applied doses of protons and carbon. The maximum effect of anesthesia was observed when irradiated with carbon ions (by 3.3 times), with protons (by 1.7 times), and with X-ray radiation (by 1.7–2 times), which should be taken into account when selecting doses. This indicates the specificity of the combined effect of anesthesia and the physical characteristics of radiation.
Supporting agencies: the work was carried out as part the state assignment No. 075-013027-23-01 and under partial financial support from the funds of the agreement between the PTC LPI RAS and ITEB RAS No. 28/22.
About the Authors
N. S. Strelnikova
Branch “Physical Technical Center”, P.N. Lebedev Physical Institute of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nataliia S. Strelnikova
142281, Moscow Region, Protvino, Mira Str., 1Н
O. M. Rozanova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga M. Rozanova
142290, Moscow Region, Pushchino, Institutskaya Str., 3
H. N. Smirnova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Helena N. Smirnova
142290, Moscow Region, Pushchino, Institutskaya Str., 3
T. A. Belyakova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences;
Institute for High Energy Physics named after A.A. Logunov of the National Research Centre “Kurchatov Institute”
Russian Federation
Russian Federation
Tatiana A. Belyakova
142290, Moscow Region, Pushchino, Institutskaya Str., 3;
142281, Moscow Region, Protvino, Science Sq., 1
E. A. Kuznetsova
Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena A. Kuznetsova, Cand. Sci. (Biol.)
142290, Moscow Region, Pushchino, Institutskaya Str., 3
References
1. Gugushvili B.S., Dzhandzhgava I.M., Kakhiani E.D., Nadareishvili K.Sh., Saneblidze O.N., Khurtsiya M.N. Radioprotektory (spravochnik) [Radioprotectors (Handbook)]. Tbilisi: Metsniereva Publ., 1987. (In Russian).
2. Ogneva N.S., Savchenko E.S., Taboyakova L.A. Anesteziya samok myshey pri khirurgicheskoy transplantatsii embrionov [Anesthesia of female mice during surgical embryo transfer]. Biomeditsina [Journal Biomed]. 2021;17(3Е):64–69. (In Russian). DOI: 10.33647/2713- 0428-17-3E-64-69
3. Durante M., Debus J., Loeffler J.S. Physics and biomedical challenges of cancer therapy with accelerated heavy ions. Nat. Rev. Phys. 2021;3(12):777–790. DOI: 10.1038/s42254-021-00368-5
4. Vanderwaeren L., Dok R., Verstrepen K., Nuyts S. Clinical progress in proton radiotherapy: Biological unknowns. Cancers (Basel). 2021;13(4):604. DOI: 10.3390/cancers13040604
5. Zhang Y.M., Yu D.X., Yin B.S., Li X.R., Li L.N., Li Y.N., Wang Y.X., Chen Y., Liu W.H., Gao L. Xylazine regulates the release of glycine and aspartic acid in rat brain. J. Vet. Res. 2018;62(1):121–128. DOI: 10.1515/jvetres-2018-0017
Review
For citations:
Strelnikova N.S., Rozanova O.M., Smirnova H.N., Belyakova T.A., Kuznetsova E.A. Effect of Xylazine/Zoletil Anesthesia on the Survival of Mice after Exposure to Radiations with Different Values of Linear Energy Transfer. Journal Biomed. 2024;20(3E):216-220. (In Russ.) https://doi.org/10.33647/2713-0428-20-3E-216-220
Views:
97
Email this article 
