Determination of Tumor Cell Sensitivity to Cytostatic Agents on the Example of Cultures of Non-Small Cell Lung Cancer in vitro
https://doi.org/10.33647/2074-5982-20-4-27-36
Abstract
Chemoresistance is a key factor restricting the use of anticancer drugs in the treatment of non-small cell lung cancer. Data on the sensitivity of tumor cells in vitro to prescribed cytostatic drugs can facilitate the prediction of cell chemoresistance for selecting optimal drugs aimed at curbing the disease and suppressing tumor growth. It is known that methods for assessing the sensitivity of cells depend on their metabolic activity. In view of this, we conducted a preliminary experiment to assess the proliferative activity of cells, which allowed us to select the concentration of cells in the exponential growth phase and calibrate the method for cell cultures.
About the Authors
K. A. Makaveeva
Scientific and Production Association «Home of Pharmacy»
Russian Federation
Russian Federation
Kseniya A. Makaveeva
188663, Leningrad Region, Vsevolozhsk District, Kuzmolovsky Village, Zavodskaya Str., 3, building 245
E. G. Kirkina
Scientific and Production Association «Home of Pharmacy»
Russian Federation
Russian Federation
Ekaterina G. Kirkina
188663, Leningrad Region, Vsevolozhsk District, Kuzmolovsky Village, Zavodskaya Str., 3, building 245
D. S. Gaidai
Scientific and Production Association «Home of Pharmacy»
Russian Federation
Russian Federation
Dmitriy S. Gaidai
188663, Leningrad Region, Vsevolozhsk District, Kuzmolovsky Village, Zavodskaya Str., 3, building 245
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Review
For citations:
Makaveeva K.A., Kirkina E.G., Gaidai D.S. Determination of Tumor Cell Sensitivity to Cytostatic Agents on the Example of Cultures of Non-Small Cell Lung Cancer in vitro. Journal Biomed. 2024;20(4):27-36. (In Russ.) https://doi.org/10.33647/2074-5982-20-4-27-36
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