Cellular Composition of Male Rat Adrenal Glands upon Urethane Administration
https://doi.org/10.33647/2074-5982-21-2-71-80
Abstract
The adrenal glands are an endocrine organ involved in the regulation of almost all vital processes in the body. Functioning of the main structural elements of the adrenal glands – corticocytes and chromaffin cells – largely depends on the cellular microenvironment. It is known that the structure of the adrenal parenchyma includes lymphocytes, macrophages, mastocytes, and other cells. Urethane is a chemical stressor that can affect the structure of the adrenal gland. This paper presents a study of the changes in the cellular composition of the adrenal glands under the administration of urethane. It was found that a single intraperitoneal injection of urethane into male rats leads to changes in the structure of the adrenal glands manifested in a decreased number of proliferating cells and mastocytes, an increased number of fibroblasts and macrophages, and infiltration of the organ with lymphocytes, mainly NK-cells.
About the Authors
N. Yu. Timofeeva
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Natalia Yu. Timofeeva
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
G. Yu. Struchko
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Gleb Yu. Struchko, Dr. Sci. (Med.), Prof.
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
L. M. Merkulova
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Larisa M. Merkulova, Dr. Sci. (Med.), Prof.
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
O. Yu. Kostrova
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Olga Yu. Kostrova, Cand. Sci. (Med.), Assoc. Prof.
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
I. S. Stomenskaya
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Irina S. Stomenskaya, Cand. Sci. (Med.), Assoc. Prof.
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
E. V. Moskvichev
I.N. Ulyanov Chuvash State University
Russian Federation
Russian Federation
Evgenij V. Moskvichev, Dr. Sci. (Med.)
428015, Chuvash Republic, Cheboksary, Moskovskiy Ave., 15
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For citations:
Timofeeva N.Yu., Struchko G.Yu., Merkulova L.M., Kostrova O.Yu., Stomenskaya I.S., Moskvichev E.V. Cellular Composition of Male Rat Adrenal Glands upon Urethane Administration. Journal Biomed. 2025;21(2):71-80. (In Russ.) https://doi.org/10.33647/2074-5982-21-2-71-80
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