Protective Properties of Prunella grandiflora L. Regarding the Genoand Cytotoxic Effects of Etoposide in a Drosophila melanogaster Model with Mutations in the FOXO gene
https://doi.org/10.33647/2074-5982-21-3-25-29
Abstract
The search for effective therapies against oncological diseases remains one of the most acute problems in modern healthcare. The side effects of chemotherapy drugs often reduce immunity and lead to multiple complications. In this work, we aimed to evaluate the protective properties of Prunella grandiflora L. against the toxic and genotoxic effects of etoposide using a Drosophila model with mutations in the dFOXO gene. Oregon-R and Foxo25 fly lines were cultured on a medium with the addition of etoposide at a concentration of 0.04 μg/ml and 10% alcoholic extract of P. grandiflora, as well as with the combined introduction of these components. The experiment established no toxic effect of P. grandiflora and its antigenotoxic, geroprotective, and neuroprotective properties in relation to the effects of the antitumor drug etoposide.
About the Authors
D. G. Zhudlovsky
Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Dmitry G. Zhudlovsky
420008, Republic of Tatarstan, Kazan, Kremlevskaya Str., 18
Ya. N. Bobkov
Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Yaroslav N. Bobkov
420008, Republic of Tatarstan, Kazan, Kremlevskaya Str., 18
O. N. Antosyuk
Ural Federal University named after the First President of Russia B.N. Yeltsin
Russian Federation
Russian Federation
Olga N. Antosyuk - Cand. Sci. (Biol.), Assoc. Prof.
620002, Yekaterinburg, Mira Str., 19
V. V. Kostenko
Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Viktoria V. Kostenko - Cand. Sci. (Biol.), Assoc. Prof.
420008, Republic of Tatarstan, Kazan, Kremlevskaya Str., 18
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Review
For citations:
Zhudlovsky D.G., Bobkov Ya.N., Antosyuk O.N., Kostenko V.V. Protective Properties of Prunella grandiflora L. Regarding the Genoand Cytotoxic Effects of Etoposide in a Drosophila melanogaster Model with Mutations in the FOXO gene. Journal Biomed. 2025;21(3):25-29. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-25-29
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