Effects of ChromoneContaining Allylmorpholines on Stress-Induced Hyperthermia in Rats
https://doi.org/10.33647/2074-5982-21-3-103-106
Abstract
In this study, we evaluated the ability of three new chromone-containing allylmorpholines (33a, 33b, and 9a) to exhibit hypothermic effects in rats after a single injection. The temperature was measured rectally before the injection and after 20, 40, and 60 min. It was found that compound 33a at doses of 50, 100, and 150 mg/kg, as well as compound 33b at a dose of 60 mg/kg, were able to decrease body temperature in rats relative to the control group at the same time point. No such effects were detected with compound 9a. These data may indicate the presence of antipsychotic action of compounds 33a and 33b.
Supporting agencies: the research was supported by a grant from the Russian Science Foundation, No. 23-75-01051 (evaluation of the effect of compound 33a and 33b) and by a Saint Petersburg State University, No. 125022102790-5 (evaluation of the effect of compound 9a)
About the Authors
N. S. Kurmazov
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Nikita S. Kurmazov
197376, Saint Petersburg, Professora Popova Str., 14, Lit. A; 197376, Saint Petersburg, Akademika Pavlova Str., 9
M. M. Puchik
Saint Petersburg State University
Russian Federation
Russian Federation
Maria M. Puchik
199034, Saint Petersburg, Universitetskaya Emb., 7–9
D. D. Shitc
Saint Petersburg State University
Russian Federation
Russian Federation
Daria D. Shitc
199034, Saint Petersburg, Universitetskaya Emb., 7–9
J. I. Sysoev
Saint Petersburg State University; I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences
Russian Federation
Russian Federation
Juryi I. Sysoev - Cand. Sci. (Biol.), Assoc. Prof.
199034, Saint Petersburg, Universitetskaya Emb., 7–9; 199034, Saint Petersburg, Makarova Emb., 6
S. V. Okovitiy
Saint Petersburg State Chemical and Pharmaceutical University of the Ministry of Health Care of Russia; N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
Russian Federation
Russian Federation
Sergey V. Okovitiy - Dr. Sci. (Med.), Prof.
197376, Saint Petersburg, Professora Popova Str., 14, Lit. A; 197376, Saint Petersburg, Akademika Pavlova Str., 9
References
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Review
For citations:
Kurmazov N.S., Puchik M.M., Shitc D.D., Sysoev J.I., Okovitiy S.V. Effects of ChromoneContaining Allylmorpholines on Stress-Induced Hyperthermia in Rats. Journal Biomed. 2025;21(3):103-106. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-103-106
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