Effect of Different Doses of Intragastric Administration of a MetalOrganic Coordination Polymer Modified with Iron Oxides and Ascorbic Acid on Serum Homeostasis Parameters and Lymphocyte Apoptosis
https://doi.org/10.33647/2074-5982-21-3-137-143
Abstract
Experiments were performed using 35 male Wistar rats. A metal-organic coordination polymer modified with iron oxide and ascorbic acid (composite) was administered intragastrically to healthy rats at doses of 25 and 50 mg/kg. The intragastric administration of the preparation under study at doses of 25 and 50 mg/kg was found to lead to a significant transient increase in serum iron concentration, while not leading to disruption of pro/antioxidant homeostasis in healthy animals. The intragastric administration of the preparation at a dose of 25 mg/kg, not 50 mg/kg, leads to the accumulation of lymphocytes in the peripheral blood at the late stage of apoptosis.
Keywords
metal-organic coordination polymer,
iron oxide nanoparticles,
ascorbic acid,
anti/prooxidant activity,
apoptosis Conflict of interest: the authors declare no conflict of interest
Supporting agencies: the research was carried out with financial support from the Russian Science Foundation, grant No. 22-73-10222
About the Authors
N. S. Tropskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Nataliya S. Tropskaya - Dr. Sci. (Biol.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3; 125993, Moscow, Volokolamskoe Highway, 4
E. V. Klychnikova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Elena V. Klychnikova - Cand. Sci. (Med.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
N. V. Borovkova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Natal’ya V. Borovkova - Dr. Sci. (Med.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
A. K. Evseev
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Anatoly K. Evseev - Dr. Sci. (Chem.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
I. V. Goroncharovskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Irina V. Goroncharovskaya - Cand. Sci. (Chem.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
M. V. Storozheva
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Mayya V. Storozheva
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
Y. N. Borodina
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Yevgeniya N. Borodina
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
L. S. Bondarenko
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department; Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Lyubov S. Bondarenko - Cand. Sci. (Chem.).
129090, Moscow, Bolshaya Sukharevskaya Sq., 3; 125993, Moscow, Volokolamskoe Highway, 4
A. A. Kochetova
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Alena A. Kochetova
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
O. V. Razbitskaya
N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Care Department
Russian Federation
Russian Federation
Olga V. Razbitskaya
129090, Moscow, Bolshaya Sukharevskaya Sq., 3
R. К. Baymuratova
Federal Research Center of Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Roza K. Baimuratova - Cand. Sci. (Chem.).
142432, Moscow Region, Chernogolovka, Acad. Semenov Ave., 1
G. I. Dzhardimalieva
Federal Research Center of Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Gulzhian I. Dzhardimalieva - Dr. Sci. (Chem.).
142432, Moscow Region, Chernogolovka, Acad. Semenov Ave., 1
K. A. Kydralieva
Moscow Aviation Institute (National Research University)
Russian Federation
Russian Federation
Kamilia A. Kydralieva - Dr. Sci. (Chem.).
125993, Moscow, Volokolamskoe Highway, 4
References
1. Tropskaya N.S., Klychnikova E.V., Borovkova N.V., Evseev A.K., Goroncharovskaya I.V., Storozheva M.V., Borodina E.N., Kochetova A.A., Bondarenko L.S., Bajmuratova R.K., Dzhardimalieva G.I., Kydralieva K.A. Issledovanie in vivo anti/prooksidantnoj aktivnosti metalloorganicheskogo koordinacionnogo polimera, modificirovannogo oksidami zheleza i askorbinovoj kislotoj [In vivo Study of the Anti/Prooxidant Activity of a MetalOrganic Coordination Polymer Modified with Iron Oxides and Ascorbic Acid]. Biomeditsina [Journal Biomed]. 2024;20(3):114–120. (In Russian)]. DOI: 10.33647/20745982-20-3-114-120.
2. Bondarenko L., Baimuratova R., Reindl M., Zach V., Dzeranov A., Pankratov D., Kydralieva K., Dzhardimalieva G., Kolb D., Wagner F.E., Schwaminger S.P. Dramatic change in the properties of magnetite-modified MOF particles depending on the synthesis approach. Heliyon. 2024;10(6):e27640. DOI: 10.1016/j.heliyon.2024.e27640.
3. Moorthy M.S., Oh Y., Bharathiraja S., Manivasagan P., Rajarathinam T., Jang B., Phan T.T.V., Jang H., Oh J. Synthesis of amine-polyglycidol functionalised Fe3O4@SiO2 nanocomposites for magnetic hyperthermia, pH-responsive drug delivery, and bioimaging applications. RSC Adv. 2016;6(111):110444–110453. DOI: 10.1039/C6RA23470D.
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For citations:
Tropskaya N.S., Klychnikova E.V., Borovkova N.V., Evseev A.K., Goroncharovskaya I.V., Storozheva M.V., Borodina Y.N., Bondarenko L.S., Kochetova A.A., Razbitskaya O.V., Baymuratova R.К., Dzhardimalieva G.I., Kydralieva K.A. Effect of Different Doses of Intragastric Administration of a MetalOrganic Coordination Polymer Modified with Iron Oxides and Ascorbic Acid on Serum Homeostasis Parameters and Lymphocyte Apoptosis. Journal Biomed. 2025;21(3):137-143. (In Russ.) https://doi.org/10.33647/2074-5982-21-3-137-143
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