.Biomodeling the Inflammatory Amyloid Cascade as the Basis of Alzheimer's Disease in Old C57BL/6J Mic
https://doi.org/10.33647/2074-5982-21-4-96-100
Abstract
In this work, the effect of chronic intranasal administration of S100A9 proinflammatory protein oligomers, inducing the inflammatory-amyloid cascade, in 24-month-old C57BL/6J mice on the formation and preservation of long-term spatial memory, Th gene expression, as well as dopamine content and metabolism in the hippocampus, frontal cortex, and cerebellum was studied. Compared to the control, experimental animals showed an impairment of the long-term memory on days 3 and 4 of training and testing session in a Morris water maze. Th expression increased significantly in the cerebellum, while dopamine levels decreased significantly in the hippocampus. Thus, chronic intranasal administration of S100A9 oligomers to old animals contributes to the formation of pathological symptoms similar to Alzheimer's disease, thus showing potential as a model of this disease.
Supporting agencies: under State assignment.
About the Authors
V. I. Inokenteva
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Victoria I. Inokenteva
125315, Moscow, Baltiyskaya Str., 8
M. A. Gruden
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Marina A. Gruden, Cand. Sci. (Chem.)
125315, Moscow, Baltiyskaya Str., 8
O. A. Solovieva
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Olga A. Solovieva
125315, Moscow, Baltiyskaya Str., 8
N. P. Mikhailova
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Nataliya P. Mikhailova
125315, Moscow, Baltiyskaya Str., 8
A. M. Ratmirov
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Alexander M. Ratmirov
125315, Moscow, Baltiyskaya Str., 8
Z. I. Storozheva
Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies
Russian Federation
Russian Federation
Zinaida I. Storozheva, Dr. Sci. (Biol.)
125315, Moscow, Baltiyskaya Str., 8
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For citations:
Inokenteva V.I., Gruden M.A., Solovieva O.A., Mikhailova N.P., Ratmirov A.M., Storozheva Z.I. .Biomodeling the Inflammatory Amyloid Cascade as the Basis of Alzheimer's Disease in Old C57BL/6J Mic. Journal Biomed. 2025;21(4):96-100. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-96-100
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