Effect of TRPV1 Channel Inhibitor on Physiological Parameters of ICR Mice under Chronic Stress
https://doi.org/10.33647/2074-5982-21-4-138-142
Abstract
Depression and anxiety disorders are among the most common psychiatric problems worldwide. The most important factor leading to the development of psychiatric disorders is chronic stress. TRPV1 channels in the central nervous system are known to be involved in neuronal plasticity and may be one of the links in the development of anxiety and depressive states. In our study, we used a selective blocker of this channel – APHC3, whose administration resulted in a reduction of anxiety and fear in animals in a model of acute stress. We have identified possible pathways for the development of psychiatric disorders when the body is exposed to chronic stress.
Supporting agencies: this work was funded from the budget of the Laboratory of Biological Tests of the Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences.
About the Authors
V. M. Pavlov
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University (ROSBIOTECH)
Puerto Rico
Puerto Rico
Vladimir M. Pavlov
142290, Moscow Region, Pushchino, Nauki Ave., 6
142290, Moscow Region, Pushchino, Nauki Ave., 3
A. Yu. Fedotova
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University (ROSBIOTECH)
Russian Federation
Russian Federation
Anastasia Yu. Fedotov
142290, Moscow Region, Pushchino, Nauki Ave., 6
142290, Moscow Region, Pushchino, Nauki Ave., 3
Ya. A. Andreev
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Russian Federation
Russian Federation
Yaroslav A. Andreev
117997, Moscow, Miklukho-Maklaya Str., 16/10
I. A. Dyachenko
Branch of the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Russian Biotechnological University (ROSBIOTECH)
Russian Federation
Russian Federation
Igor A. Dyachenko
142290, Moscow Region, Pushchino, Nauki Ave., 6
142290, Moscow Region, Pushchino, Nauki Ave., 3
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Review
For citations:
Pavlov V.M., Fedotova A.Yu., Andreev Ya.A., Dyachenko I.A. Effect of TRPV1 Channel Inhibitor on Physiological Parameters of ICR Mice under Chronic Stress. Journal Biomed. 2025;21(4):138-142. (In Russ.) https://doi.org/10.33647/2074-5982-21-4-138-142
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