Seasonal dynamics of indicators of physical health of laboratory animals

Abstract

The study was performed as a retrospective analysis of the results of previous studies on preclinical researches of new chemical compounds promising as a means of improving efficiency. We analyzed the control group of animals received in the course of the kinezohydrodinamic study, forced swimming test with a load, test on rota-rod with rats, running on a treadmill to failure with mini-pigs. It is shown that the influence of the factor "season" for all analyzed parameters was statistically significant. The most important it was for the index test on rota-rod, endurance and maximum swimming speed in kinezohydrodinamic study. Moderate importance of seasonality factor has been set for the index average swimming speed, performance indicators and fatigue in kinezohydrodinamic study. Seasonality hardly has any effect on the time limit of swimming animals with load and mini-pigs running on a treadmill to failure. Thus, the more extreme impact test animal, the less significant is the seasonal factor. The results need to be considered when planning preclinical studies aimed at assessing the physical performance of animals.