CYP2C19*2, CYP2C19*3, CYP2C19*17 allele and genotype frequencies in clopidogrel-treated patients with coronary heart disease from the Russian population
Abstract
Individual variation in the response to drug therapy has been mainly attributed to the genetic polymorphism of cytochrome P 450 isoenzymes. We examined 40 patients with CHD, who received clopidogrel and 146 healthy volunteers. CYP2C19*2, CYP2C19*3, CYP2C19*17 carriage was determined by a polymerase chain reaction. 20 clopidogrel-treated patients had the CYP2C19 *1/*1 genotype (50%), 12 – CYP2C19 *1/*2 (30,0%), 5 – CYP2C19 *1/*17 (12,5%), and 3 – CYP2C19 *17/*17 (7,5%). Among the healthy volunteers, 111-CYP2C19 *1/*1 (76,1%), 31 – CYP2C19 *1/*2 (21, 2%), and 4 – CYP2C19*2/*2 (2,7%). The frequencies of CYP2C19*2 were 15,0% and 13,3% in patients with CHD and in healthy volunteers respectively (p=0,323). The results of the present study show the impact of individual response variability to clopidogrel on clinical outcomes and may be helpful in developing current and future directions for its management.
About the Authors
K. B. Mirzaev
Первый Московский государственный медицинский университет имени И.М. Сеченова, Москва
Russian Federation
Russian Federation
D. A. Sychev
Первый Московский государственный медицинский университет имени И.М. Сеченова, Москва
Russian Federation
Russian Federation
V. N. Karkischenko
ФГБУН «Научный центр биомедицинских технологий ФМБА России», Московская область
Russian Federation
Russian Federation
A. V. Grachev
«СМ-клиника», Москва
Russian Federation
Russian Federation
G. P. Knyazev
«СМ-клиника», Москва
Russian Federation
Russian Federation
R. E. Kazakov
«СМ-клиника», Москва
Russian Federation
Russian Federation
A. V. Korasev
Первый Московский государственный медицинский университет имени И.М. Сеченова, Москва
Russian Federation
Russian Federation
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Review
For citations:
Mirzaev K.B., Sychev D.A., Karkischenko V.N., Grachev A.V., Knyazev G.P., Kazakov R.E., Korasev A.V. CYP2C19*2, CYP2C19*3, CYP2C19*17 allele and genotype frequencies in clopidogrel-treated patients with coronary heart disease from the Russian population. Journal Biomed. 2013;1(1):117-122. (In Russ.)
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