Laser Correlation Features organismal response of mice of different lines to acute gamma-irradiation

Abstract

Exposure to ionizing radiation leads to exhaustion of the pool of stem cells, increases differentiated cell stress, and activated reparation and apoptosis processes. Apart from well-documented acute effects, radiotherapy leads to delayed effects manifesting in few years after successful treatment. The aim of our study was the development of a test battery for evaluation of irradiation aftereffects in organisms characterized by different radiosensitivity. In C3H/Sn and 101/Hf mice, light scattering spectrum was shifted towards small particles, while in C57BL mice increased contribution of large particles was observed. In 3 weeks, a shift towards larger particles was recorded in all three mouse strains, but its degree varied. By week 6, the histograms approached the control. Histological study showed that the incidence of severe injuries in the liver increased by the end of the experiment in C57BL mice (but not in other mouse strains). The same shifts were observed in the pancreas and an opposite tendency was seen in the spleen. Thus, C57BL mice responded to irradiation later that C3H/Sn and 101/Hf mice, but demonstrated high adaptation capacity. C3H/Sn mice best of all recovered from the radiation crisis.