Experimental modeling of chronic warm insufficiency

Abstract

Introduction of new methods of treatment of chronic warm insufficiency demands the adequate evidential base including preclinical researches on experimental models at animals. Successful approbation of several experimental models of formation of warm insufficiency at the laboratory animals allowing by means of a method of an echocardiography to investigate various options of a course of a disease, both on expressiveness of hemodynamic manifestations, and on primary defeat of departments of heart is carried out. The most effective in terms of reproducibility and intensity of the changes is the model with a permanent ligation of the left coronary artery. Among the features of pharmacological models doxorubicin model of chronic heart failure is a progressive decrease in left ventricular contractility and the development of his eccentric remodeling, whereas izadrin model is characterized by the development of a moderate heart failure, and the introduction of monocrotaline is mainly the development of pulmonary hypertension, right ventricular hypertrophy and severe right heart failure.