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A comparative study of toxicological properties of a oxovanadium (IV) complex and his metallohelat ligand

Abstract

Aladyshkina The purpose of the work has consisted in comparative studying acute toxicity, cumulative activity of a new organic oxovanadium (IV) complex bis{tret-butyl[amino(imino)methyl]carbamato}oxydovanadium (IV) (BAMK) and his ligand tret-butoxycarbonylguanidine (BKG) and to the estimation of their influence on morphology of internals in comparison with vanadyl sulfate. Values of LD50 for the BAMK, BKG and vanadyl sulfate has averaged 178 mg / kg, 1003 mg / kg and 407 mg / kg correspondingly. According to the scale of Hodge and Sterner it is possible to attribute BAMK and BKG as the compounds with moderately toxic substances, and BKG – as compound with low toxicity. Because of research cumulation activity it has been shown, those БАМК and vanadyl sulfate have high cumulative activity, and BKG does not cumulate in internals of animals.

About the Authors

N. M. Vorobyeva
ГОУ ВПО Санкт-Петербургская химико-фармацевтическая академия
Russian Federation


E. V. Fedorova
ГОУ ВПО Санкт-Петербургская химико-фармацевтическая академия
Russian Federation


A. V. Buryakina
ГОУ ВПО Санкт-Петербургская химико-фармацевтическая академия
Russian Federation


E. K. Vishnevskaya
ГОУ ВПО Санкт-Петербургская химико-фармацевтическая академия
Russian Federation


T. V. Gorbacheva
Бюро судебно-медицинской экспертизы, Санкт-Петербург
Russian Federation


А. A.e
Бюро судебно-медицинской экспертизы, Санкт-Петербург
Russian Federation


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Review

For citations:


Vorobyeva N.M., Fedorova E.V., Buryakina A.V., Vishnevskaya E.K., Gorbacheva T.V., A.e  A comparative study of toxicological properties of a oxovanadium (IV) complex and his metallohelat ligand. Journal Biomed. 2013;1(4):6-15. (In Russ.)

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