Application platelet-rich plasma in clinical practice

The most actual aspects of application in various areas of medicine of modern biomedical technology – platelet-rich plasma are reflected in article. In the last decade is celebrated significant increase in interest to this biotechnology that is caused by its high efficiency at high level of safety and low prime cost. Now platelet-rich plasma actively it is applied in surgery, stomatology, traumatology and orthopedics, sports medicine, cosmetology and dermatology, a combustiology. At the same time apparent defect of an assessment of application efficiency and the remote results autoplasm from the point of view of evidential medicine is still noted. Platelet-rich plasma possesses a number of useful properties: accelerates processes of regeneration of fabrics, anti-inflammatory effect, decrease in a pain syndrome that opens still big prospects for application in surgery, traumatology.

обогащенная тромбоцитами аутоплазма, регенерация, травматология, хирургия, дерматология, стоматология, комбустиология, спортивная медицина, Autoplasm enriched by thrombocyte, regeneration, traumatology, surgery, dermatology, stomatology, combustiology, sports medicine

1. Аминова З.М., Емелин А.Л., Овечкина М.В., Калянова Е.В. Применение богатой тромбоцитами плазмы в ортопедии Технология PlasmoliftingТМ Процедура Orthoplasma Методическое пособие для врачей, Москва 2012г.

2. Ахмеров Р.Р., Зарудий Р.Ф. Применение обогащенной аутоплазмы для лечения фотодерматоза. г. Уфа ФГУ Всероссийский центр глазной и пластической хирургии. Реферат. 2003 г.

3. Башкина А.С., Широкова Л.Ю., Абросимова Е.Б., Бахтиярова Т.И., Носков С.М. Обогащённая тромбоцитами плазма в лечении болевого синдрома большого вертела. – Спортивная медицина: наука и практика. – №1, 2012 – с.7-10.

4. Безуглов Э.Н., Ачкасов Е.Е., Усманова Э.М., Куршев В.В., Султанова О.А., Заборова В.А., Суворов В.Г., Сёдерхольм Л.А. Применение тромбоцитарных факторов роста при лечении повреждений латеральных связок голеностопного сустава у футболистов. – Спортивная медицина: наука и практика. -№1, 2013 – с.31-35

5. Безуглов Э.Н., Глущенко А.Л., Ачкасов Е.Е., Ядрошвили А.Э., Каркищенко Н.Н. Первый опыт применения тромбоцитарных факторов роста при лечении повреждений опорно-двигательного аппарата спортсменов высокой квалификации. – Материалы V Международной конференции по вопросам состояния и перспективам развития медицины в спорте высших достижений «СпортМед-2010». Москва, 9-10 декабря 2010 г. – с.53-55.

6. Брехов В.Л. Хирургическое лечение больных с дефектами костной и хрящевой тканей с применением богатой тромбоцитами аутоплазмы. дис. канд. мед. наук. Курск. - 2007г

7. Войно-Ясенецкий В.Ф. Очерки гнойной хирургии. -Бином, 2006. - С. 720.

8. Зинин В.Ю., Кожевников А.М., Зотов В.А. Использование богатой тромбоцитами плазмы в лечении больных с венозными трофическими язвами. ГОУ ВПО Новосибир55 Е.Е. Ачкасов, Э.Н. Безуглов, А.А. Ульянов, В.В. Куршев, А.Д. Репетюк, О.Н. Егорова ский государственный медицинский университет, Новосибирск, Россия -2007 г.

9. Сычевский М. В. Эффективность модифицированной повязки на основе коллагена типа I при лечении обширных ожоговых ран III А степени. Дис. канд. мед. наук. Москва -2010.

10. Хубутия М.Ш., Смирнов С.В., Сычевский М.В., Бочарова B.C. /Значение тромбоцитарного фактора роста (PDGF-BB) в сочетании с губчатым коллагеновым матриксом в лечении ожогов И-Ша степени./ Клеточные технологии и регенеративная медицина в хирургии и трансплантологии: материалы гор. науч.-практ. конф.- М.: НИИ СП им. Н.В. Склифосовского, 2009.-(Труды ин-та, Т.207).-С.7-10.

11. Чекмарева, И.А. Процессы репаративной регенерации в ранах при лечении биологически активными перевязочными средствами (экспериментально -морфологическое исследование): автореф. дисс. д-ра. биол. наук.- М., 2002.-41с.

12. Anand SX, Viles-Gonzales JF, Badimon JJ, et all. (2003) Membrane-associated CD40L and sCD40L in atherothrombotic disease. Throm Haemost 90:377–384

13. Anitua E, Andia I, Ardanza B, et all. (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Tromb Haemost 91:4–15

14. Batten ML, Hansen JC, Dahners LE (1996) Influence of dosage and timing of application of platelet-derived growth factor on early healing of the rat medial collateral ligament. J Orthop Res 14:736–741

15. Buckwalter JA, Mankin HJ (1997) Articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and tranplantation. J Bone Joint Surg 79A:612–632

16. Chen CH, Cao Y, Wu YF, et all. (2008) Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period. J Hand Surg Am 33:1834–1842

17. Creaney L, Hamilton B (2008) Growth factor delivery methods in the management of sports injuries: the state of play. Br J Sports Med 42:314–320

18. De Vos RJ, Weir A, van Schie HT, et all. (2010) Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. JAMA 13(303):144–149

19. Eming S.A., Yarmush M.L., Krueger G.G. et all / Regulation of the spatial organization of mesenchymal connective tissue: effects of cell-associated versus released isoforms of plateletderived growth factor // Am. J. Pathol.1999.- Vol. 154.-P.281 -289.

20. Filardo G, Kon E, Della Villa S, et all. (2010) Use of platelet-rich plasma for the treatment of refractory jumper’s knee. Int Orthop 34:909–915

21. Floryan K, Berghoff WJ (2004) Intraoperative use of autologous platelet rich and platelet poor plasma for orthopaedic surgery patients. AORN J 80:668–674

22. Foster TE, Puskas BL, Mandelbaum BR, et all. (2009) Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 37:2259–2272

23. Froum S.J., Wallace S.S., Tarnow D.P., et all. Effects of platelet-reach plasma on bone growth and osseоintegration in human maxillary sinus grafts: Three

24. Применение аутоплазмы, обогащенной тромбоцитами, в клинической практике bilateral case reports // Int J Periodontics Restorative Dent. – 2002. - №22. – Р. 45-53

25. Gugat R.(2013) PRP experiences in muscle end tendon injuries: clinical experience with footballers. Football Medicine Strategies for Muscle end Tendon Injuries-113

26. Harrison, P. Platelet alpha-granules / P. Harrison, E.M. Cramer // Blood. Rev.1993.- №7.-P.52-62.

27. Hildebrand K, Woo S, Smith D, et all. (1998) The effect of platelet-derived growth factor- BB on healing of the rabbit medial collateral ligament. An in vivo study. Am J Sports Med 26:549

28. Kaetzel, D.M. Transcriptional control of the platelet-derived growth factor subunit genes / D.M. Kaetzel, D.W. Coyne, R.A. Fenstermaker // Biofac.-l 993.-Vol.4.-№2.-P.71-81

29. Kasemkijwattana C, Menetrey J, Bosch P, et all. (2000) Use of growth factors to improve muscle healing after strain injury. Clin Orthop Relat Res 370:272–285

30. Kobayashi M, Itoi E, Minagawa H, et all. (2006) Expression of growth factors in the early phase of supraspinatus tendon healing in rabbits. J Shoulder Elbow Surg 15:371–377

31. Kon E, Buda R, Filardo G, et all. (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 18:472–479

32. Lee J, Harwood FL, Akeson WH, et all. (1998) Growth factor expression in healing rabbit medial collateral and anterior cruciate ligaments. Iowa Orthop J18:19–25

33. Letson AK, Dahners L (1994) The effects of combinations of growth factors on ligament healing. Clin Orthop Relat Res 308:207–212

34. Lind M, Jakobsen BW, Lund B, et all. (2009) Anatomical reconstruction of the medial collateral ligament and posteromedial corner of the knee in patients with chronic medial collateral ligament instability. Am J Sports Med 37:1116–1122

35. Lopez-Vidriero E, Goulding KA, Simon DA, et all. (2010) The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy 26:269–Lundberg M, Messner K (1996) Longterm prognosis of isolated partial medial collateral ligament ruptures. A ten-year clinical and radiographic evaluation of a prospectively observed group of patients. Am J Sports Med 24:160–163

36. Maniscalco P, Gambera D, Lunati A, et all. (2008) The ‘‘Cascade’’ membrane: a new PRP device for tendon ruptures. Description and case report on rotator cuff tendon. Acta Biomed 79:223–226

37. Marx RE (2004) Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surgery 62:489–496

38. Mishra A, Woodall J Jr, Vieira A (2009) Treatment of tendon and muscle using platelet-rich plasma. Clin Sports Med 28:113–125

39. Miyazno K. et all Receptors for transforming grow factor – beta, Adv. Immunology. – 1994 – Vol. 55. – P. 181-220

40. Molloy T, Wang Y, Murrell G (2003) The roles of growth factors in tendon and ligament healing. Sports Med 33:381–394

41. Е.Е. Ачкасов, Э.Н. Безуглов, А.А. Ульянов, В.В. Куршев, А.Д. Репетюк, О.Н. Егорова

42. Mustoe T.A., Pierce G.F., Thomason A. et al. // Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta / Science.-1987.-Vol.237.-P. 1333-1336.

43. Nagumo A, Yasuda K, Numazaki H, et all. (2005) Effects of separate application of three growth factors (TGF-beta1, EGF, and PDGF-BB) on mechanical properties of the in situ frozenthawed anterior cruciate ligament. Clin Biomech 20:283–290

44. Parkkari J, Pasanen K, Mattila VM, et all. (2008) The risk for a cruciate ligament injury of the knee in adolescents and young adults: a population-based cohort study of 46 500 people with a 9 year follow-up. Br J Sports Med 42:422–426

45. Peerbooms JC, Sluimer J, Bruijn DJ, et all. (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet rich plasma versus corticosteroid injection with a 1-year followup. Am J Sports Med 38:255–262

46. Pujol JP, Chadjichristos C, Legendre F, et all. (2008) Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism. Connect Tissue Res 49:293–297

47. Randelli P, Arrigoni P, Cabitza P, et all. (2008) Autologous platelet rich plasma for arthroscopic rotator cuff repair. A pilot study. Disabil Rehabil 30:1584– 1589

48. Rubio-Zaragoza M, Damia E, Ceron R, et all.Experimental study on the influence of Intramuscular injection of Plasma Rich Growth Factors in serum Insuline like Growth Factors-I and C-Reactive Protein in the DOG. 15th ESSKA Congress, Geneva, May 2-5, 2012(Р-35-1192)

49. Sammut L.(2013) Achilles tendinopathy in football players: is there a role for platelet rich plasma injection. Football Medicine Strategies for Muscle end Tendon Injuries-234

50. Sampson S, Gerhardt M, Mandelbaum B (2008) Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med 1:165–174

51. Sаnchez M, Anitua E, Azofra J, et all. (2008) Intraarticular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol 26:910–913

52. Stellos K, Kopf S, Paul A, et all. (2010) Platelets in regeneration. Semin Thromb Hemost 36:175–184

53. Tyapongsak P., et all., Autologius fibrin adhesive in mandibular reconstruction with participate cancellers bone and marrow // J. Oral Maxillofacial. Surg.1994.- Vol. 52. - P. 161-166.

54. Urist M.R. Bone morphogenetic protein / M.R.Urist, B.S.Strates // J. Dent. Res. - 1972. - Vol. 50. - P. 1392.

55. Virchenko O, Aspenberg P (2006) How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks? Interplay between early regeneration and mechanical stimulation. Acta Orthop Scand 77:806–812

56. Westermark B., Siegbahn A. , Heldin C., et all. B-type receptor for plateletderived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein- tyrosine kinase / // PNAS.-1990.-Vol.87.-P. 128-132.

57. Woo SL, Smith DW, Hildebrand KA, et all. (1998) Engineering the healing of the rabbit medial collateral ligament. Med Biol Eng Comput 36:359–364.