The rat work capacity in forced swimming test with load and causes it variability
Abstract
The drug administration rout, body mass and atmospheric pressure effects on the rat work capacity in forced swimming test with 10% from body mass load were investigated. The rat work capacity was tested at the 1, 8, 15 and 22-nd days of intragastral or intramuscular distilled water administration. At the 8, 15 and 22-nd experimental days the rat swimming time was increased in comparison with 1-st day test results. At the 15-th day work capacity in rat group with intragastral rout was greater than in the group with intramuscular injection. The rat swimming time had inverted correlation with body mass and relative epididymidal fat mass. Atmospheric pressure had no effect on the mean swimming time in rats groups, but rats with individual sensibility to atmospheric pressure was detected. The individual sensibility of rat to atmospheric pressure was greater in rat group with intramuscular injection than in group with intragastral administration rout.
About the Authors
M. S. Zaytseva
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
D. G. Ivanov
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
N. V. Alexandrovskaya
ФГУП «НЦ «Сигнал»
Russian Federation
Russian Federation
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Zaytseva M.S., Ivanov D.G., Alexandrovskaya N.V. The rat work capacity in forced swimming test with load and causes it variability. Journal Biomed. 2015;1(4):30-42. (In Russ.)
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