Nebivolol influence on myocardial polyamines metabolism in a rat model of regenerative & plastic heart failure
Abstract
Endogenous polyamines (putrescine, spermidine, & spermine) plays an important role in the process
of ongoing myocardial injury in the regenerative & plastic heart failure. One of the possible mechanisms
of β-blockers induced cardioprotection in the failing heart is their modulation effect on the polyamines
metabolism. Cardioselective β1-blocker nebivolol is shown to partially normalize an essentially disturbed
myocardial level of putrescine, spermidine & spermine in adriamycin-induced regenerative & plastic heart
failure in rats.
of ongoing myocardial injury in the regenerative & plastic heart failure. One of the possible mechanisms
of β-blockers induced cardioprotection in the failing heart is their modulation effect on the polyamines
metabolism. Cardioselective β1-blocker nebivolol is shown to partially normalize an essentially disturbed
myocardial level of putrescine, spermidine & spermine in adriamycin-induced regenerative & plastic heart
failure in rats.
About the Authors
Д. Хлопонин¹
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
Ю. Макляков¹
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
Ю. Кротова¹
Ростовский государственный медицинский университет, Ростов-на-Дону
Russian Federation
Russian Federation
В. Каркищенко²
Научный центр биомедицинских технологий РАМН, Московская обасть
Russian Federation
Russian Federation
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, , , Nebivolol influence on myocardial polyamines metabolism in a rat model of regenerative & plastic heart failure. Journal Biomed. 2012;1(1):10-15. (In Russ.)
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