Neurotoxic profile of the new adenine derivative with antivirial activity
Abstract
The aim of the reseach was to study pharmacoplogical properties, top determine safety effect diapason
toxicoplogical properties of new adenine derivative 9-[2-(4-isopropylphenopxy)aethyl] adenine under
laboratory code VMA-99-82 which reveals antivirial activity in vitro. The results of the reseach of neurotopxic
profile of the combination VMA-99-82 are presented in the work; methodics of multitest watching accoding
to «S.Irvin» being used. In the course of the reseach in was determined safety level the substans VMA-99-82
refers to the class of low toxic copmbination. The diapopson of doses (from 18.7 to 300 mg/kg) of the substans
evident therapeutical effect in which accompanying side-effect are not essentialy revealedwas determined.
Therapeutical effect of the combination VMA-99-82 is mostly in the field of bechavioral reactions, which
presents interest for further deep stady of psychotropic effect the substance effect mechanism.
toxicoplogical properties of new adenine derivative 9-[2-(4-isopropylphenopxy)aethyl] adenine under
laboratory code VMA-99-82 which reveals antivirial activity in vitro. The results of the reseach of neurotopxic
profile of the combination VMA-99-82 are presented in the work; methodics of multitest watching accoding
to «S.Irvin» being used. In the course of the reseach in was determined safety level the substans VMA-99-82
refers to the class of low toxic copmbination. The diapopson of doses (from 18.7 to 300 mg/kg) of the substans
evident therapeutical effect in which accompanying side-effect are not essentialy revealedwas determined.
Therapeutical effect of the combination VMA-99-82 is mostly in the field of bechavioral reactions, which
presents interest for further deep stady of psychotropic effect the substance effect mechanism.
About the Authors
Д. Ковалев
НИИ фармакологии Волгоградского государственного медицинского университета,
Волгоград
Russian Federation
Russian Federation
Н. Мохаммад Амин
Волгоградский государственный медицинский университет, Волгоград
Russian Federation
Russian Federation
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Review
For citations:
, Neurotoxic profile of the new adenine derivative with antivirial activity. Journal Biomed. 2012;1(1):139-142. (In Russ.)
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