Role of nitric oxide in the regulation of peritoneal macrophages in rats offspring chronic disturbance of the uteroplacental blood circulation
Abstract
Еxam of the activity of peritoneal macrophages, NO-dependent state and mechanisms of free radical pro-
cesses in normal pregnancy and in the background of the experimental disturbance of the utero-placental
circulation (DUPC) was done with using of white rats.
With the introduction of L-NAME and DUPC in serum observed similar changes in the form of lower
levels of total nitrate and nitrite, increasing free radical processes. Activity of peritoneal macrophages varies
in the opposite way - L-NAME significantly increases her, and DUPC - decreases. When combined action of
increased production of nitric oxide formation and nitrotirozine that under these conditions plays a protective
role by providing adaptation impaired feto-placental blood flow to the needs of the fetus, the activity of mac-
rophages corresponds to the intact rats.
cesses in normal pregnancy and in the background of the experimental disturbance of the utero-placental
circulation (DUPC) was done with using of white rats.
With the introduction of L-NAME and DUPC in serum observed similar changes in the form of lower
levels of total nitrate and nitrite, increasing free radical processes. Activity of peritoneal macrophages varies
in the opposite way - L-NAME significantly increases her, and DUPC - decreases. When combined action of
increased production of nitric oxide formation and nitrotirozine that under these conditions plays a protective
role by providing adaptation impaired feto-placental blood flow to the needs of the fetus, the activity of mac-
rophages corresponds to the intact rats.
About the Authors
А. Иванова
Ивановская государственная медицинская академия, Минздравсоцразвития РФ,
Иваново
Russian Federation
Russian Federation
И. Попова
Ивановский НИИ материнства и детства им. В.Н. Городкова, Минздравсоцразвития
РФ, Иваново
Russian Federation
Russian Federation
С. Назаров
Ивановская государственная медицинская академия, Минздравсоцразвития РФ,
Иваново
Ивановский НИИ материнства и детства им. В.Н. Городкова, Минздравсоцразвития
РФ, Иваново
Russian Federation
Russian Federation
A. S. Ivanova
Russian Federation
I. G. Popova
Russian Federation
S. B. Nazarov
Russian Federation
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, , , Ivanova A.S., Popova I.G., Nazarov S.B. Role of nitric oxide in the regulation of peritoneal macrophages in rats offspring chronic disturbance of the uteroplacental blood circulation. Journal Biomed. 2012;1(2):61-67. (In Russ.)
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