Possibilities of the fluorescent (spectral) express analysis of firm medicinal forms
Abstract
Fluorescence spectra, fluorescence excitation spectra of tableted form of papaverine hydrochloride and drotaverine hydrochloride and spectra the drugs standards were measured and studied. It was shown that spectral characteristics of drotaverine have a long-wave shift in comparison with spectral characteristics of papaverine that could be explained by the fact that drotaverine molecule has more adjacent conjugated bonds than papaverine molecule. Correlative and multivariate statistical analysis (method of principal components) of studied drugs tableted forms spectra allows to identify the drugs with an accuracy not less than 99,99. The present research confirmed the possibility of drugs quality analysis in the presence of adjuvants.
About the Authors
Yu. G. Zyuzkova
ФГБУ «НИИ Фармакологии» СО РАМН
Russian Federation
Russian Federation
V. E. Prokopyev
Институт сильноточной электроники СО РАН
Russian Federation
Russian Federation
V. V. Udut
ФГБУ «НИИ Фармакологии» СО РАМН
Russian Federation
Russian Federation
L. G. Vorobyeva
Russian Federation
N. N. Karkischenko
Russian Federation
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Review
For citations:
Zyuzkova Yu.G., Prokopyev V.E., Udut V.V., Vorobyeva L.G., Karkischenko N.N. Possibilities of the fluorescent (spectral) express analysis of firm medicinal forms. Journal Biomed. 2012;1(4):38-44. (In Russ.)
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