Correction of hormonal and metabolic changes of age-specific hypogonadism in male rats with recombinant human lactoferrin
Abstract
Our study of the rat model of age-related hypogonadism revealed reduced serum levels of testosterone and some its predecessors in steroidogenesis (progesterone and 17-OH progesterone). Against this background, there was an increase of estradiol, resulting in a significant decrease of testosterone/estradiol index in 2-year rats during the experiment. Systemic administration per os of recombinant human lactoferrin to experimental animals had a significant stimulatory effect on testosterone biosynthesis in 2-year-olds, restoring it to the level of physiological values in young rats. Alongside with this, there also occurred a significant decrease in serum levels of luteinizing (not follicle stimulating) hormone - by 26,4% as compared with the control group of 2 year old animals.
About the Authors
Yu. A. Rudnichenko
Институт физиологии НАН Беларуси
Russian Federation
Russian Federation
V. S. Lukashevich
Институт физиологии НАН Беларуси
Russian Federation
Russian Federation
I. V. Zalutskiy
Институт физиологии НАН Беларуси
Russian Federation
Russian Federation
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Review
For citations:
Rudnichenko Yu.A., Lukashevich V.S., Zalutskiy I.V. Correction of hormonal and metabolic changes of age-specific hypogonadism in male rats with recombinant human lactoferrin. Journal Biomed. 2017;(1):52-62. (In Russ.)
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