Prospects of clinical application of multipotent mesenchymal stromal cells for regeneration of hyaline cartilaginous tissue
Abstract
Developed biotransplant for intra-articular introduction multipotent mesenchymal stromal cells (MMSC) adipose tissue (AT) and gel media to promote regeneration of hyaline cartilage tissue. Selection of cells based on the ability of MMSCs to differentiate into adipose cartilage cells (chondroblasts and chondrocytes) for induction to chondrodysplastic. Optimal carrier to deliver the cells in the defect, the consistency is similar to synovial fluid, supporting the viability, proliferative activity and chondrogenic potential of MSC inside the joint. It is demonstrated that with intra-articular introduction of rabbits biotransplant consisting of autologous MMSC AT and gel media on the basis of derivatives of cellulose is a complete regeneration of the defect with hyaline cartilaginous tissue.
About the Authors
S. V. Korzhikova
Центр клеточных технологий ООО «Бьюти Плаза»
Russian Federation
Russian Federation
E. V. Frolov
Центр клеточных технологий ООО «Бьюти Плаза»
Russian Federation
Russian Federation
Z. A. Teplyashin
Центр клеточных технологий ООО «Бьюти Плаза»
Russian Federation
Russian Federation
V. N. Volovenko
ФГБОУ ВО «Ярославский государственный медицинский Университет» Минздрава России
Russian Federation
Russian Federation
A. S. Teplyashin
Центр клеточных технологий ООО «Бьюти Плаза»
Russian Federation
Russian Federation
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Review
For citations:
Korzhikova S.V., Frolov E.V., Teplyashin Z.A., Volovenko V.N., Teplyashin A.S. Prospects of clinical application of multipotent mesenchymal stromal cells for regeneration of hyaline cartilaginous tissue. Journal Biomed. 2017;(2):23-32. (In Russ.)
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