Method for evaluating the xenobiotic detoxification system in laboratory animals

Abstract

In order to more accurately assess the safety of research in pre-clinical studies have proposed the technique of an estimation of system of detoxification of xenobiotics in laboratory animals. The study was performed on two species of laboratory animals - frogs and rats. As toxic xenobiotic used two medications with fundamentally different mechanisms of action and different ways of detoxification: ethyl alcohol and cisplatin. Scoring of toxic action of xenobiotics was carried out by the method of expert scaling. Thus, the study showed that the effectiveness of the detoxification system of xenobiotics can be judged according to their Toxicological studies acute toxicity on the basis of the dynamics of the total point scoring of severity of signs of intoxication.